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Products:Immunology >> Innate Immunity >> Complement >> Other
Overview
Product name
Anti-A2ML1 antibody
Description
Mouse polyclonal to A2ML1
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Full length protein, corresponding to amino acids 1-158 of Human A2ML1
Positive control
A2ML1 transfected 293T cell lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 1X PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Protease inhibitors >> Other protease inhibitors
Immunology >> Innate Immunity >> Complement >> Other
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Western blot - A2ML1 antibody (ab72872)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab72872 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500Predicted molecular weight: 18 kDa.
Target
Relevance
A2ML1 is a new member of the alpha 2-macroglobulin protease inhibitor family, and shares most the characteristics of this family. It is the first family member detected in the epidermis and may play an important role during desquamation by inhibiting extracellular proteases. The alpha-macroglobulin (AM) superfamily of proteins contains both complement components and protease inhibitors, including A2M and A2ML1. AM proteins display a unique trap mechanism of inhibition, by which the AM inhibitor undergoes a major conformational change upon its cleavage by a protease, thus trapping the protease and blocking it from subsequent substrate binding.
Cellular localization
Secreted
Alternative names
- CPAMD9 antibody
- A2ML 1 antibody
- Alpha 2 macroglobulin like 1 antibody
see all
Database links
- Entrez Gene: 144568 Human
- Omim: 610627 Human
- SwissProt: A8K2U0 Human
Anti-A2ML1 antibody images:
Western blot - A2ML1 antibody (ab72872)
All lanes : Anti-A2ML1 antibody (ab72872) at 1/500 dilution
Lane 1 : A2ML1 transfected 293T cell lysate
Lane 2 : non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
Predicted band size : 18 kDa
Observed band size : 20 kDa (why is the actual band size different from the predicted?)
References for Anti-A2ML1 antibody (ab72872)
ab72872 has not yet been referenced specifically in any publications.
Publishing research using ab72872? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"