AACOCF3 (Arachidonyl trifluoromethyl ketone), Phospholipase-A2 inhibitor (ab120350)
Key features and details
- Phospholipase-A2 inhibitor
- CAS Number: 149301-79-1
Supplied in ethanol (10 mg/ml)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
AACOCF3 (Arachidonyl trifluoromethyl ketone), Phospholipase-A2 inhibitor -
Description
Phospholipase-A2 inhibitor -
Alternative names
- Arachidonyl trifluoromethyl ketone
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Biological description
Cell-permeable analog of arachidonic acid (ab120916). Widely used as an inhibitor of the 85-kDa cytosolic group IV phospholipase A2 (cPLA2) and calcium-independent group VI phospholipase A2 (iPLA2) (IC50 values are 1.5 and 6.0 μM, respectively) . In non-neural cells, also inhibits cyclooxygenase and acyltransferase activities.
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CAS Number
149301-79-1 -
Chemical structure
Properties
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Chemical name
(6Z,9Z,12Z,15Z)-1,1,1-Trifluorohenicosa-6,9,12,15-tetraen-2-one
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Molecular weight
356.47 -
PubChem identifier
5280436 -
Storage instructions
Store at -20°C. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Supplied in ethanol (10 mg/ml)
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
FC(F)(F)C(=O)CCCC=C/C/C=CC/C=CC/C=CCCCCC -
Source
Synthetic
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Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab120350 has been referenced in 1 publication.
- Monson EA et al. Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response. Nat Commun 12:4303 (2021). PubMed: 34262037