Anti-AADAC antibody (ab54694)

Overview

• Product nameAnti-AADAC antibodySee all AADAC primary antibodies ...
• Description
  Mouse monoclonal to AADAC
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Recombinant Fragment
  Predicted to work with: Human
• Immunogen

  Recombinant fragment: QLLDDPDVKI KLKIQSLIYP ALQPLDVDLP SYQENSNFLF LSKSLMVRFW SEYFTTDRSL EKAMLSRQHV PVESSHLFKF INWSSLLPER FIKGHVYNNP , corresponding to amino acids 201-301 of Human AADAC

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  PBS, pH 7.2
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• IsotypeIgG2b
• Light chain typekappa
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Drug metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Signal Transduction
  • Metabolism
  • Drug metabolism

Applications

Target

• FunctionArylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.
• Tissue specificityMainly expressed in liver, small intestine, colon and adrenal gland.
• Sequence similaritiesBelongs to the 'GDXG' lipolytic enzyme family.
• Cellular localizationEndoplasmic reticulum membrane. Microsome membrane.

Target information above from: UniProt accession P22760 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 13 Human
  • Omim: 600338 Human
  • SwissProt: P22760 Human
  • Unigene: 506908 Human

• Alternative names
  AAAD_HUMAN antibodyAada antibodyAadac antibody

  Arylacetamide deacetylase (esterase) antibodyArylacetamide deacetylase antibodyCES5A1 antibodyDAC antibody

  see all

Anti-AADAC antibody images

• 

  Western blot - AADAC antibody (ab54694)
  Western blot against tagged recombinant protein immunogen using ab54694 AADAC antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa.

  This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.