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Overview

  • Product nameAADAC protein (His-DHFR tag)
  • Protein descriptionRecombinant fragment of Human AADAC (amino acids 200-399) with an N terminal His-DHFR tag. Predicted MWt 23.2 kDa excluding tag (BC032309).
  • Uniprot accessionP22760
  • Molecular weight23.200kDa
  • Protein length200 amino acids
  • Expression hostE. coli

    • Properties

  • Purification notesPurity 50% by SDS-PAGE
  • E.C. Number3.1.1.3
  • FormLyophilised:Reconstitute with water to desired concentration.
  • Storage instructionsShipped at 4°C. Store at -20ºC.
  • Storage bufferConstituents: 0.32% Tris HCl, 0.58% Sodium chloride
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab127832 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        AAAD_HUMANAadaAadac
        Arylacetamide deacetylaseArylacetamide deacetylase (esterase)CES5A1DAC
      see all
  • FunctionArylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.
  • Tissue specificityMainly expressed in liver, small intestine, colon and adrenal gland.
  • Sequence similaritiesBelongs to the 'GDXG' lipolytic enzyme family.
  • Cellular localizationEndoplasmic reticulum membrane. Microsome membrane.

    • Target information above from: UniProt accession P22760 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for AADAC protein (His-DHFR tag) (ab127832)

    ab127832 has not yet been referenced specifically in any publications.

    Publishing research using ab127832 ? Please let us know so that we can cite the reference in this datasheet

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