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Overview

  • Product nameAADACL1 protein (His-DHFR tag)See all AADACL1 proteins and peptides ...
  • Protein descriptionRecombinant fragment corresponding to amino acids 202-417 of Human AADACL1 with N terminal His-DHFR tag; Predicted MWt 24.1 kDa excluding tag (BC028734).
  • Uniprot accessionQ6PIU2
  • Molecular weight24.100kDa
  • Protein length216 amino acids
  • Expression hostE. coli

    • Properties

  • Purification notesPurity determined to be 80% by SDS-PAGE.
  • E.C. Number3.1.1.-
  • FormLyophilised:Reconstitute with water to desired concentration.
  • Storage instructionsShipped at 4°C. Store at -20ºC.
  • Storage bufferConstituents: 0.32% Tris HCl, 0.58% Sodium chloride
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab127377 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        Arylacetamide deacetylase like 1Arylacetamide deacetylase-like 1NCEH
        Nceh1NCEH1_HUMANNeutral cholesterol ester hydrolaseNeutral cholesterol ester hydrolase 1
      see all
  • FunctionHydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.
  • Tissue specificityExpressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.
  • Sequence similaritiesBelongs to the 'GDXG' lipolytic enzyme family.
  • Post-translational
    modifications    N-glycosylated.
  • Cellular localizationMembrane. Microsome.

    • Target information above from: UniProt accession Q6PIU2 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for AADACL1 protein (His-DHFR tag) (ab127377)

    ab127377 has not yet been referenced specifically in any publications.

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