Overview

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • AccessionQ6PIU2
    • SpeciesHuman
    • Molecular weight24 kDa
    • Amino acids202 to 417
    • TagsHis-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127377 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • ReconstitutionReconstitute with water to desired concentration.

General info

  • Alternative names
    • Arylacetamide deacetylase like 1
    • Arylacetamide deacetylase-like 1
    • NCEH
    • Nceh1
    • NCEH1_HUMAN
    • Neutral cholesterol ester hydrolase
    • Neutral cholesterol ester hydrolase 1
    see all
  • FunctionHydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.
  • Tissue specificityExpressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.
  • Sequence similaritiesBelongs to the 'GDXG' lipolytic enzyme family.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localizationMembrane. Microsome.
  • Information by UniProt

References for AADACL1 protein (His-DHFR tag) (ab127377)

ab127377 has not yet been referenced specifically in any publications.

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