Overview

  • Product name
    AAL 993
  • Description
    Potent, selective and cell-permeable VEGFR inhibitor
  • Biological description
    Potent, selective and cell-permeable VEGFR inhibitor (IC50 values are 130, 23 and 18 nM for VEGFR1, 2, and 3 respectively). Inhibits VEGF-induced angiogenesis in vivo. Suppresses hypoxia-induced HIF-1α expression without affecting Akt phosphorylation in vitro.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Ban HS  et al. Suppression of hypoxia-induced HIF-1alpha accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633. Cancer Lett 296:17-26 (2010). Read more (PubMed: 20378243) »
  • Manley PW  et al. Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis. Biochim Biophys Acta 1697:17-27 (2004). Read more (PubMed: 15023347) »
  • Manley PW  et al. Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem 45:5687-93 (2002). Read more (PubMed: 12477352) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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