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Products:Neuroscience >> Neurotransmitter >> Amino Acids >> GABA
Overview
Product name
Anti-ABAT antibody
See all ABAT products (4) ...
Description
Mouse polyclonal to ABAT
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Full length human ABAT protein (NP_000654.2)
Positive control
Human liver lysate; lysate from ABAT transfected 293T cells.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Response to hypoxia
Signal Transduction >> Metabolism >> Mitochondrial
Neuroscience >> Neurotransmitter >> Amino Acids >> GABA
Applications
Show applications key
Our Abpromise guarantee covers the use of ab72765 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000.Predicted molecular weight: 56 kDa.
Target
Function
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Tissue specificity
Liver > pancreas > brain > kidney > heart > placenta.
Involvement in disease
Defects in ABAT are a cause of gamma-aminobutyrate transaminase deficiency (GABA-AT deficiency) [MIM:613163]. The phenotype of this deficiency includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.
Sequence similarities
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Cellular localization
Mitochondrion matrix.
Target information above from: UniProt accessionP80404
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- mitochondrial antibody
- (S) 3 amino 2 methylpropionate transaminase antibody
- (S)-3-amino-2-methylpropionate transaminase antibody
see all
Database links
- Entrez Gene: 18 Human
- Omim: 137150 Human
- SwissProt: P80404 Human
- Unigene: 336768 Human
Anti-ABAT antibody images:
Western blot - ABAT antibody (ab72765)
Anti-ABAT antibody (ab72765) at 1/500 dilution + human liver lysate at 25 µg
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugated at 1/2500 dilution
Predicted band size : 56 kDa
Western blot - ABAT antibody (ab72765)
All lanes : Anti-ABAT antibody (ab72765) at 1/500 dilution
Lane 1 : ABAT transfected 293T cell line lysate
Lane 2 : non transfected 293T cell line lysate
Lysates/proteins at 25 µg per lane.
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugated at 1/2500 dilution
Predicted band size : 56 kDa
References for Anti-ABAT antibody (ab72765)
ab72765 has not yet been referenced specifically in any publications.
Publishing research using ab72765? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"