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Product Name
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ABCA7 antibody [4A7-144.1] (Phycoerythrin)
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See all ABCA7 antibodies (2)...
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Product type
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Primary antibodies
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Description
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Rat monoclonal [4A7-144.1] to ABCA7 (Phycoerythrin)
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Immunogen
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ABCA7-transfected HeLa cells
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Reacts with
(species key)
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Ms
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Tested applications
(see key)
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Flow Cyt
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Flow Cyt: Use 10µl for 106 cells.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Mouse spleen cells.
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Cellular localization
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Cell Membrane and Cytoplasmic
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Research areas
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Signal Transduction >> Metabolism >> Lipid metabolism
Signal Transduction >> Metabolism >> Plasma Membrane >> ATPases
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism
Neuroscience >> Cell Type Marker >> Glia marker >> Astrocyte marker
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Relevance
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ATP-binding cassette (ABC)1 transporters are a superfamily of highly conserved membrane proteins that transport a wide variety of substrates including ions, amino acids, peptides, sugars, lipids, and sterols across cell membranes.
ABCA7 is a full-size ABC transporter, the physiological function of which is unclear. This is a protein that shows the highest homology known to ABCA1, an essential molecule for producing of plasma high-density lipoprotein (HDL), and in fact it mimics ABCA1 to mediate the production of HDL from cellular lipid when transfected in vitro. ABCA7 might play a relevant role in regulating lipid metabolism.
Mutations of ABC transporters have been identified as the cause of at lease 12 different genetic disorders.
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Database links
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The links below go to external sites and will open in a new browser window Entrez Gene | | 27403 (Mouse)
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Raised in
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Rat
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Clonality
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Monoclonal
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Clone number
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4A7-144.1
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Isotype
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IgG2a
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Purity
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Protein G purified
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Storage buffer
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Preservative: 0.09% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Conjugation
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Phycoerythrin
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Concentration
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0.100 mg/ml
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Storage instructions
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Store at +4°C in the dark. Do not freeze.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this ABCA7 antibody [4A7-144.1] (Phycoerythrin) is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to ABCA7
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ABCA7 antibody [4A7-144.1] (Phycoerythrin) - more information
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