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Anti-ABCB11 antibody - Carboxyterminal end
See all ABCB11 products (3) ...
Rabbit polyclonal to ABCB11 - Carboxyterminal end
We have received some negative reports from customers using this antibody in IHC, therefore we do not recommend this antibody for IHC.
WB, ELISAmore details
Reacts with
Mouse, Human
A KLH conjugated synthetic peptide selected from the C-terminal region of human ABCB11.
Human hepatocarcinoma tissue and mouse liver tissue lysate.
Liquid
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.09% Sodium Azide
Constituents: PBS
Concentration information loading...
Protein G purified
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Polyclonal
IgG
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Signal Transduction >> Metabolism >> Lipid metabolism
Signal Transduction >> Metabolism >> Plasma Membrane >> Channels
Western blot - ABCB11 antibody - Carboxyterminal end (ab71793)
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Our Abpromise guarantee covers the use of ab71793 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/100 - 1/500.Detects a band of approximately 146 kDa (predicted molecular weight: 146 kDa).
ELISA: 1/1000
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis type 2 (PFIC2) [MIM:601847]. PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
Defects in ABCB11 are the cause of benign recurrent intrahepatic cholestasis type 2 (BRIC2) [MIM:605479]. BRIC is characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration and patients are asymptomatic between episodes, both clinically and biochemically.
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.
Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
Membrane.
Target information above from: UniProt accessionO95342
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Western blot - ABCB11 antibody - Carboxyterminal end (ab71793)

Anti-ABCB11 antibody - Carboxyterminal end (ab71793) at 1/100 dilution + mouse liver tissue lysate at 12.5 µg
Predicted band size : 146 kDa
Observed band size : 146 kDa
ab71793 has not yet been referenced specifically in any publications.
Publishing research using ab71793? Please let us know so that we can cite the reference in this datasheet
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