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Anti-ABCB4 antibody [P3II-26] (ab24108)

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Overview

Product name

Anti-ABCB4 antibody [P3II-26]
See all ABCB4 products (3) ...

Description

Mouse monoclonal [P3II-26] to ABCB4

Specificity

Clone P3II-26 does not cross-react with the human ABCB1.

Tested applications

ICC, IHC-Fr, WB, Flow Cytmore details

Cross reactivity

Reacts with

Human

Immunogen

Fusion protein: NMQTSGSQIQ SEEFELNDEK AATRMAPNGW KSRLFRHSTQ KNLKNSQMCQ KSLDVETDGL EANV, corresponding to Internal sequence amino acids 629-692 of Human ABCB4.

NMQTSGSQIQ SEEFELNDEK AATRMAPNGW KSRLFRH STQ KNLKNSQMCQ KSLDVETDGL EANV

Epitope

Clone P3II-26 reacts with an internal epitope of ABCB4.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: 0.7% BSA, serum-free tissue culture supernatant

Purity

Tissue culture supernatant

Clonality

Monoclonal

Clone number

P3II-26

Isotype

IgG2b

Applications

Show applications key

Our Abpromise guarantee covers the use of ab24108 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

Is unsuitable for or IHC-P.

Target

Function

Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human MDR3 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.

Involvement in disease

Defects in ABCB4 are the cause of progressive familial intrahepatic cholestasis type 3 (PFIC3) [MIM:602347]. PFIC3 is an autosomal recessive liver disorder presenting with early onset cholestasis that progresses to cirrhosis and liver failure before adulthood. It is characterized by elevated serum gamma-glutamyltransferase levels.
Defects in ABCB4 are a cause of intrahepatic cholestasis of pregnancy (ICP) [MIM:147480]; also known as obstetric cholestasis. ICP is a multifactorial liver disorder of pregnancy. It presents during the second or, more commonly, the third trimestre of pregnancy with intense pruritus which becomes more severe with advancing gestation and cholestasis. Cholestasis results from abnormal biliary transport from the liver into the small intestine. ICP causes fetal distress, spontaneous premature delivery and intrauterine death. ICP patients have spontaneous and progressive disappearance of cholestasis after delivery.
Defects in ABCB4 are a cause of gallbladder disease type 1 (GBD1) [MIM:600803]. It is one of the major digestive diseases. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations in western countries. Most people with gallstones, however, remain asymptomatic through their lifetimes.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.

Cellular localization

Cell membrane.

Target information above from: UniProt accessionP21439 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • ABC 21 antibody
  • ABC B4 antibody
  • ABC21 antibody
  • ABCB 4 antibody
  • Abcb4 antibody
  • ABCB4 protein antibody
  • ATP binding cassette sub family B MDR/TAP member 4 antibody
  • ATP binding cassette sub family B member 4 antibody
  • ATP-binding cassette sub-family B member 4 antibody
  • MDR 3 antibody
  • MDR2 antibody
  • MDR2/3 antibody
  • MDR3 antibody
  • MDR3 P glycoprotein antibody
  • MDR3 P gp antibody
  • MDR3_HUMAN antibody
  • Multidrug resistance protein 3 antibody
  • Multiple drug resistance 3 antibody
  • P glycoprotein 3 antibody
  • P-glycoprotein 3 antibody
  • PFIC 3 antibody
  • PFIC3 antibody
  • PGY 3 antibody
  • PGY3 antibody
see all

References for Anti-ABCB4 antibody [P3II-26] (ab24108)

This product has been referenced in:

  • Scheffer GLet al. Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Cancer Res 60:5269-77 (2000).Read more (PubMed: 11016657) »

See 1 publication for this product

Publishing research using ab24108? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"