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Anti-ABCB5 antibody (ab80108)

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Overview

Product name

Anti-ABCB5 antibody
See all ABCB5 products (3) ...

Description

Rabbit polyclonal to ABCB5

Tested applications

ELISA, WBmore details

Cross reactivity

Reacts with

Human

Immunogen

KLH conjugated synthetic peptide selected from the N terminal region of human ABCB5

Positive control

K562 cell line lysate

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.09% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

Ammonium Sulphate Precipitation

Purification notes

ab80108 is prepared by Saturated Ammonium Sulfate precipitation followed by dialysis against PBS.

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Drug resistance >> P glycoproteins
Signal Transduction >> Metabolism >> Plasma Membrane >> Channels

  • Western blot - ABCB5 antibody - N-terminal (ab80108)Western blot - ABCB5 antibody - N-terminal (ab80108) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab80108 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ELISA

     ELISA: 1/1000

    ELISA: 1/1000

  • ShowHide1 Image

    WB

     WB: 1/50 - 1/100.Predict...Read more →

    WB: 1/50 - 1/100.Predicted molecular weight: 90 kDa.

Target

Function

Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.

Tissue specificity

Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Contains 1 ABC transmembrane type-1 domain.
Contains 2 ABC transporter domains.

Cellular localization

Cell membrane.

Target information above from: UniProt accessionQ2M3G0 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • ABCB 5 antibody
  • ABCB5 antibody
  • ABCB5 P-gp antibody
  • ABCB5_HUMAN antibody
  • ABCB5alpha antibody
  • ABCB5beta antibody
  • ATP binding cassette sub family B (MDR/TAP) member 5 antibody
  • ATP binding cassette sub family B member 5 antibody
  • ATP-binding cassette sub-family B member 5 antibody
  • EST422562 antibody
  • P glycoprotein ABCB5 antibody
  • P-glycoprotein ABCB5 antibody
see all

Database links

Anti-ABCB5 antibody images:

  Western blot - ABCB5 antibody - N-terminal (ab80108)

Western blot - ABCB5 antibody - N-terminal (ab80108)

Anti-ABCB5 antibody (ab80108) at 1/50 dilution + K562 cell line lysates at 35 µg

Predicted band size : 90 kDa
Observed band size : 90 kDa

References for Anti-ABCB5 antibody (ab80108)

ab80108 has not yet been referenced specifically in any publications.

Publishing research using ab80108? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"