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Overview

  • Product nameABCB5 protein (Tagged)
  • Protein descriptionRecombinant fragment corresponding to amino acids 587-790 of Human ABCB5 (BC104894) with a His-DHFR tag.
  • Uniprot accessionQ2M3G0
  • Protein length204 amino acids
  • Expression hostE. coli

    • Properties

  • Purification notesPurity is >95% by SDS-PAGE
  • FormLyophilised:Reconstitute with water to desired concentration.
  • Storage instructionsStore at -20°C.
  • Storage bufferConstituents: 0.32% Tris HCl, 0.58% Sodium chloride, 28.8% Guanidine HCl
  • Concentration information loading...
  • Sequence notesILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQ GQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENI AYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGL KGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSE KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKI KEQG
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab125989 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        ABCB 5ABCB5ABCB5 P-gp
        ABCB5_HUMANABCB5alphaABCB5betaATP binding cassette sub family B (MDR/TAP) member 5ATP binding cassette sub family B member 5ATP-binding cassette sub-family B member 5EST422562P glycoprotein ABCB5P-glycoprotein ABCB5
      see all
  • FunctionPlasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.
  • Tissue specificityExpressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.
  • Sequence similaritiesBelongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
    Contains 1 ABC transmembrane type-1 domain.
    Contains 2 ABC transporter domains.
  • Cellular localizationCell membrane.

    • Target information above from: UniProt accession Q2M3G0 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for ABCB5 protein (Tagged) (ab125989)

    ab125989 has not yet been referenced specifically in any publications.

    Publishing research using ab125989 ? Please let us know so that we can cite the reference in this datasheet

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