Anti-ABCB6 antibody - C-terminal (ab224575)

Overview

  • Product name
    Anti-ABCB6 antibody - C-terminal
    See all ABCB6 primary antibodies
  • Description
    Rabbit polyclonal to ABCB6 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human ABCB6 aa 786-842 (C terminal).
    Sequence:

    STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDT KPQTMER


    Database link: Q9NP58

  • Positive control
    • IHC-P: Human testis tissue. ICC/IF: U-251 MG cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab224575 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100.

Target

  • Function
    Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.
  • Tissue specificity
    Widely expressed. Highest expression in heart and skeletal muscles.
  • Sequence similarities
    Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
    Contains 1 ABC transmembrane type-1 domain.
    Contains 1 ABC transporter domain.
  • Developmental stage
    Highly expressed in fetal liver.
  • Cellular localization
    Mitochondrion outer membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ABC antibody
    • ABC transporter umat antibody
    • ABC14 antibody
    • Abcb6 antibody
    • ABCB6_HUMAN antibody
    • ATP binding cassette sub family B member 6, mitochondrial precursor antibody
    • ATP binding cassette, sub family B (MDR/TAP), member 6 antibody
    • ATP-binding cassette half-transporter antibody
    • ATP-binding cassette sub-family B member 6 antibody
    • ATP-binding cassette sub-family B member 6, mitochondrial antibody
    • DUH3 antibody
    • LAN antibody
    • MCOPCB7 antibody
    • Mitochondrial ABC transporter 3 antibody
    • mitochondrial antibody
    • Mt ABC transporter 3 antibody
    • Mt-ABC transporter 3 antibody
    • MTABC3 antibody
    • P glycoprotein related protein antibody
    • P-glycoprotein-related protein antibody
    • PRP antibody
    • Ubiquitously expressed mammalian ABC half transporter antibody
    • Ubiquitously-expressed mammalian ABC half transporter antibody
    • UMAT antibody
    see all

Images

  • Paraffin-embedded human testis tissue stained for ABCB6 using ab224575 at 1/20 dilution in immunohistochemical analysis.

  • PFA-fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells stained for ABCB6 (green) using ab224575 at 4 µg/ml in ICC/IF.

References

ab224575 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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