Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Cardiovascular >> Hypoxia >> Hypoxia-Regulated
Overview
Product name
Anti-ABCB6 antibody
Description
Rabbit polyclonal to ABCB6
Tested applications
ICC/IF, ELISA, WBmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat
Immunogen
Synthetic peptide: RAMNTQENATRARAVD, corresponding to internal sequence amino acids 440-455 of Human ABCB6
RAMNTQENAT RARAVD
Positive control
KB cells transfected with the ABCB6 protein.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: 0.15M Sodium chloride, 0.02M Potassium phosphate, pH 7.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Drug resistance >> P glycoproteins
Signal Transduction >> Metabolism >> Mitochondrial
Cardiovascular >> Hypoxia >> Hypoxia-Regulated
-
Western blot - ABCB6 antibody (ab47837)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab47837 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC/IF
ELISA
- 1 Image
WB
Application notes
ELISA: 1/40000 - 1/200000.
IF (microscopy): Use at an assay dependent dilution.
WB: 1/1000 - 1/5000. Predicted molecular weight: 93 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
The membrane-associated protein ABCB6 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.
Cellular localization
Mitochondrial outer membrane, multi-pass membrane protein
Alternative names
- ABC antibody
- ABC transporter umat antibody
- ABC14 antibody
see all
Database links
- Entrez Gene: 10058 Human
- Entrez Gene: 74104 Mouse
- Entrez Gene: 140669 Rat
- Omim: 605452 Human
- SwissProt: Q9NP58 Human
- SwissProt: Q9DC29 Mouse
- SwissProt: O70595 Rat
- SwissProt: Q9Z1S2 Rat
see all
Anti-ABCB6 antibody images:
Western blot - ABCB6 antibody (ab47837)
All lanes : Anti-ABCB6 antibody (ab47837) at 1/1400 dilution
Lane 1 : KB cell lysate expressing Flag™-tagged human ABCB6 protein
Lane 2 : KB cell lysate without a vector insert
Predicted band size : 93 kDa
Observed band size : 104 kDa (why is the actual band size different from the predicted?)
Additional bands at : 79 kDa (possible truncated form).
References for Anti-ABCB6 antibody (ab47837)
ab47837 has not yet been referenced specifically in any publications.
Publishing research using ab47837? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"