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Overview

  • Product nameABCB6 protein (His tag)
  • Protein descriptionRecombinant fragment of Human ABCB6 corresponding to amino acids 598-818, with an N terminal His tag. Predicted MWt 23.6 kDa excluding tag, (BC000559; Q9NP58)
  • Uniprot accessionQ9NP58
  • Molecular weight23.600kDa
  • Protein length221 amino acids
  • Expression hostE. coli

    • Properties

  • Purification notesPurity is >95% by SDS-PAGE.
  • FormLyophilised:Reconstitute with water to desired concentration.
  • Storage instructionsShipped at 4°C. Store at -20ºC.
  • Storage bufferConstituents: 0.32% Tris HCl, 0.58% Sodium chloride
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab127452 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        ABCABC transporter umatABC14
        Abcb6ABCB6_HUMANATP binding cassette sub family B member 6, mitochondrial precursorATP binding cassette, sub family B (MDR/TAP), member 6ATP-binding cassette sub-family B member 6mitochondrialMitochondrial ABC transporter 3Mt ABC transporter 3Mt-ABC transporter 3MTABC3P glycoprotein related proteinP-glycoprotein-related proteinPRPUbiquitously expressed mammalian ABC half transporterUbiquitously-expressed mammalian ABC half transporterUMAT
      see all
  • FunctionBinds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.
  • Tissue specificityWidely expressed. Highest expression in heart and skeletal muscles.
  • Sequence similaritiesBelongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
    Contains 1 ABC transmembrane type-1 domain.
    Contains 1 ABC transporter domain.
  • Developmental stageHighly expressed in fetal liver.
  • Cellular localizationMitochondrion outer membrane.

    • Target information above from: UniProt accession Q9NP58 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for ABCB6 protein (His tag) (ab127452)

    ab127452 has not yet been referenced specifically in any publications.

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