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Products:Signal Transduction >> Metabolism >> Energy Metabolism
Overview
Product name
Anti-ABCB7 antibody
See all ABCB7 products (2) ...
Description
Rabbit polyclonal to ABCB7
Specificity
This antibody reacts with ABCB7
Tested applications
IHC-P, ELISAmore details
Cross reactivity
Reacts with
Human
Immunogen
Synthetic human ABCB7 peptide conjugated to KLH
Epitope
Amino acids 733 to 747 of human ABCB7
Positive control
Thymus tissue
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Erythrocytic Lineage
Signal Transduction >> Metabolism >> Energy Metabolism
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ABCB7 antibody (ab65149)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab65149 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use a concentration of 10 µg/ml
ELISA
ELISA: 1/10 - 1/1000.ELISA: 1/10 - 1/1000.
Target
Function
Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.
Involvement in disease
Defects in ABCB7 are the cause of X-linked sideroblastic anemia with ataxia (ASAT) [MIM:301310]. ASAT is a recessive disorder characterized by an infantile to early childhood onset of nonprogressive cerebellar ataxia and mild anemia with hypochromia and microcytosis.
Sequence similarities
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
Contains 1 ABC transmembrane type-1 domain.
Contains 1 ABC transporter domain.
Cellular localization
Mitochondrion inner membrane.
Target information above from: UniProt accessionO75027
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- mitochondrial antibody
- ABC transporter 7 protein antibody
- ABC7 antibody
see all
Database links
- Entrez Gene: 22 Human
- Omim: 300135 Human
- SwissProt: O75027 Human
- Unigene: 370480 Human
Anti-ABCB7 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ABCB7 antibody (ab65149)
ab65149 at 10µg/ml staining ABCB7 in Formalin-Fixed Paraffin-Embedded human thymus tissue.
References for Anti-ABCB7 antibody (ab65149)
ab65149 has not yet been referenced specifically in any publications.
Publishing research using ab65149? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"