Overview
Product nameABCB8 protein (His-DHFR tag)
Protein descriptionRecombinant fragment corresponding to amino acids 450-687 of Human ABCB8 with N terminal His-DHFR tag; Predicted MWt 25.8 kDa excluding tag (BC141836).
Uniprot accessionA5D8W3
Molecular weight25.800kDa
Protein length238 amino acids
Expression hostE. coli
Properties
Purification notesPurity determined to be >95% by SDS-PAGE.
FormLyophilised:Reconstitute with water to desired concentration.
Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferConstituents: 0.32% Tris HCl, 0.58% Sodium chloride
Concentration information loading...
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab127222
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Application
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Notes |
| SDS-PAGE |
SDS-PAGE: Use at an assay dependent dilution. |
Protein info
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Alternative names
ATP binding cassette sub family B member 8ATP binding cassette sub family B (MDR/TAP) member 8ATP binding cassette sub family B member 8 mitochondrial
EST328128M ABC1MABC1Mitochondrial ABC proteinMitochondrial ATP binding cassette 1
see all
RelevanceABCB8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCB8 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. ABCB8 may also play a role in the transport of phospholipids into mitochondrial membranes.
Cellular localizationMitochondrion inner membrane; Multi-pass membrane protein.
References for ABCB8 protein (His-DHFR tag) (ab127222)
ab127222
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
