Anti-ABCC10 antibody [M7I-3] (ab91451)
Key features and details
- Rat monoclonal [M7I-3] to ABCC10
- Suitable for: ICC
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ABCC10 antibody [M7I-3]
See all ABCC10 primary antibodies -
Description
Rat monoclonal [M7I-3] to ABCC10 -
Host species
Rat -
Tested applications
Suitable for: ICCmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment within Human ABCC10 aa 150-300 (internal sequence). The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.3
Preservative: 0.1% Sodium azide
Constituent: 0.7% BSA
Serum free tissue culture supernatant -
Concentration information loading...
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Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
M7I-3 -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab91451 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ICC |
1/20 - 1/50.
Acetone fixed cytospin preparations. |
Notes |
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ICC
1/20 - 1/50. Acetone fixed cytospin preparations. |
Target
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Function
ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. -
Tissue specificity
Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed. -
Sequence similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 89845 Human
- Omim: 612509 Human
- SwissProt: Q5T3U5 Human
- Unigene: 55879 Human
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Alternative names
- ABCC10 antibody
- ATP binding cassette, sub family C (CFTR/MRP), member 10 antibody
- ATP binding cassette, subfamily C, member 10 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab91451 has been referenced in 8 publications.
- Shi B et al. Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells. Oncol Lett 20:148 (2020). PubMed: 32934716
- Wang X et al. SDF-1a/MicroRNA-134 Axis Regulates Nonfunctioning Pituitary Neuroendocrine Tumor Growth via Targeting VEGFA. Front Endocrinol (Lausanne) 11:566761 (2020). PubMed: 33362712
- Wei W et al. The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1. Oncol Res 28:423-438 (2020). PubMed: 32331534
- Orellana-Serradell O et al. The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines. Asian J Androl N/A:N/A (2019). PubMed: 30880686
- Wang H et al. Effects of histone deacetylase inhibitors on ATP-binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells. Oncol Lett 18:63-71 (2019). PubMed: 31289473
- Zhang L et al. miR-361 enhances sensitivity to 5-fluorouracil by targeting the FOXM1-ABCC5/10 signaling pathway in colorectal cancer. Oncol Lett 18:4064-4073 (2019). PubMed: 31579069
- Xu R & Han Y Long non-coding RNA FOXF1 adjacent non-coding developmental regulatory RNA inhibits growth and chemotherapy resistance in non-small cell lung cancer. Arch Med Sci 15:1539-1546 (2019). PubMed: 31749883
- De Souza R et al. Chemotherapy dosing schedule influences drug resistance development in ovarian cancer. Mol Cancer Ther 10:1289-99 (2011). WB ; Mouse . PubMed: 21551263