![Immunocytochemistry - ABCC11 antibody [M8I-74] (ab91452) image](#ABCC11-Primary-antibodies-ab91452-1.jpg)
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- Secondary antibodies
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Product name
Anti-ABCC11 antibody [M8I-74]
See all ABCC11 products (4) ...
Description
Rat monoclonal [M8I-74] to ABCC11
Tested applications
Flow Cyt, WB, IHC-Fr, ICCmore details
Cross reactivity
Reacts with
Human
Immunogen
Fusion protein corresponding to N terminal amino acids 1 - 83 of Human ABCC11.
MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQD GPWSQQERNPEAPGRAAVPPWGKYDAALRTMIPFRPKPRF PAP
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 0.7% BSA, Tissue culture supernatant
Purity
Tissue culture supernatant
Clonality
Monoclonal
Clone number
M8I-74
Isotype
IgG
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Drug metabolism
Cancer >> Drug resistance >> MRP-related proteins
Signal Transduction >> Metabolism >> Drug metabolism
Signal Transduction >> Metabolism >> Plasma Membrane >> ATPases
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Immunocytochemistry - ABCC11 antibody [M8I-74] (ab91452)
![Immunocytochemistry - ABCC11 antibody [M8I-74] (ab91452) image](/ps/datasheet/images/91/ab91452/ABCC11-Primary-antibodies-ab91452-1.jpg)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab91452 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt
WB
IHC-Fr
- 1 Image
ICC
Application notes
Flow Cyt (acetone fixed cytospin preparations): Use at an assay dependent dilution.
ICC: 1/20 - 1/50.
IHC-Fr: 1/20.
WB: 1/20 - 1/50. Predicted molecular weight: 154 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
ABCC11 belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily. It contains two ABC transmembrane type-1 domains and two ABC transporter domains. ABCC11 participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides and enhances the cellular extrusion of cAMP and cGMP. It also stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. It probably functions to secrete earwax.
Cellular localization
Membrane; Multi-pass membrane protein.
Alternative names
- ABCC 11 antibody
- ATP binding cassette protein C11 antibody
- ATP binding cassette sub family C (CFTR/MRP) member 11 antibody
see all
Database links
- Entrez Gene: 85320 Human
- Omim: 607040 Human
- SwissProt: Q96J66 Human
Anti-ABCC11 antibody [M8I-74] images:
Immunocytochemistry - ABCC11 antibody [M8I-74] (ab91452)
ab91452 at 1/50 dilution staining ABCC11 in ABCC11 transfected human HEK cells by Immunocytochemistry. Image show positive staining of non-transfected and ABCC11 transfected HEK cells.
References for Anti-ABCC11 antibody [M8I-74] (ab91452)
ab91452 has not yet been referenced specifically in any publications.
Publishing research using ab91452? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"