ABCC11 antibody (ab76727)

Product Name 

ABCC11 antibody

Product type 

Primary antibodies

Description 

Mouse monoclonal to ABCC11

Immunogen 

Recombinant fragment: FVPIAVKGLT NSKSAVMRFK KFFLQESPVF YVQTLQDPSK ALVFEEATLS WQQTCPGIVN GALELERNGH ASEGMTRPRD ALGPEEEGNS LGPELHKINL, corresponding to amino acids 433-533 of Human ABCC11 (NP_115972) with tag.
BLAST 'FVPIAVKGLT NSKSAVMRFK KFFLQESPVF YVQTLQDPSK ALVFEEATLS WQQTCPGIVN GALELERNGH ASEGMTRPRD ALGPEEEGNS LGPELHKINL ' with or

Reacts with 

RecFrag

Predicted to react 
(species key)

Hu, Chmp, RMk
(Due to sequence homology)

Tested applications 
(see key)

ELISA, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
ELISA: Use at an assay dependent dilution.
WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 154 kDa.

This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Recombinant tagged human ABCC11 fragment.

Cellular localization 

Membrane; Multi-pass membrane protein.

Research areas 

Cancer >> Drug resistance >> MRP-related proteins
Signal Transduction >> Metabolism >> Drug metabolism
Signal Transduction >> Metabolism >> Plasma Membrane >> ATPases

Relevance 

ABCC11 belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily. It contains two ABC transmembrane type-1 domains and two ABC transporter domains.

ABCC11 participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides and enhances the cellular extrusion of cAMP and cGMP. It also stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. It probably functions to secrete earwax.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Isotype 

IgG2a

Light chain type 

kappa

Purity 

Protein A purified

Storage buffer 

Preservative: None
Constituents: 1X PBS, pH 7.2

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

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