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Products:Signal Transduction >> Metabolism >> Plasma Membrane >> ATPases
Overview
Product name
Anti-ABCC11 antibody
See all ABCC11 products (4) ...
Description
Goat polyclonal to ABCC11
Specificity
This antibody is expected to recognize both reported isoforms (NP_115972.2; NP_660187.1).
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide: C-KVVEFDRPEVLRK from the internal region (near the C terminus) of the human ABCC11 protein sequence according to NP_115972.2; NP_660187.1.
KVVEFDRPEV LRK
Positive control
Human breast and human testis lysates.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris saline, pH 7.3
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Drug resistance >> MRP-related proteins
Signal Transduction >> Metabolism >> Drug metabolism
Signal Transduction >> Metabolism >> Plasma Membrane >> ATPases
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Western blot - ABCC11 antibody (ab82152)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab82152 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
ELISA
Application notes
Peptide ELISA: Antibody detection limit dilution 1/32,000.
WB: Use at a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 154 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
ABCC11 belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily. It contains two ABC transmembrane type-1 domains and two ABC transporter domains. ABCC11 participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides and enhances the cellular extrusion of cAMP and cGMP. It also stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. It probably functions to secrete earwax.
Cellular localization
Membrane; Multi-pass membrane protein.
Alternative names
- ABCC 11 antibody
- ATP binding cassette protein C11 antibody
- ATP binding cassette sub family C (CFTR/MRP) member 11 antibody
see all
Database links
- Entrez Gene: 85320 Human
- Omim: 607040 Human
- SwissProt: Q96J66 Human
Anti-ABCC11 antibody images:
Western blot - ABCC11 antibody (ab82152)
Anti-ABCC11 antibody (ab82152) at 0.5 µg/ml + human breast lysate in RIPA buffer at 35 µg
developed using the ECL technique
Predicted band size : 154 kDa
Observed band size : 125 kDa (why is the actual band size different from the predicted?)
Exposure time : 1 hour
References for Anti-ABCC11 antibody (ab82152)
ab82152 has not yet been referenced specifically in any publications.
Publishing research using ab82152? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"