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Overview

  • Product nameABCD1 protein (His-DHFR tag)
  • Protein descriptionRecombinant fragment corresponding to amino acids 560-737 of Human ABCD1 with an N terminal His-DHFR tag; 20 kDa calculated without tag (NM_000033).
  • Uniprot accessionP33897
  • Molecular weight20kDa
  • Protein length178 amino acids
  • Expression hostE. coli

    • Properties

  • Purification notes80% by SDS Page
  • FormLyophilised:Reconstitute with water to desired concentration
  • Storage instructionsShipped at 4°C. Store at -20ºC.
  • Storage bufferConstituents: 0.32% Tris HCl, 0.58% Sodium chloride
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab127510 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        ABC42Abcd1ABCD1_HUMAN
        Adrenoleukodystrophy proteinALDAldghALDPAMNATP binding cassette, sub family D (ALD), member 1ATP-binding cassette sub-family D member 1OTTHUMP00000025960OTTMUSP00000019283RGD1562128RP23 373N8.2X linked adrenoleukodystrophy (ALD) gene homolog
      see all
  • FunctionProbable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
  • Involvement in diseaseDefects in ABCD1 are the cause of adrenoleukodystrophy X-linked (X-ALD) [MIM:300100]. X-ALD is a peroxisomal metabolic disorder characterized by progressive multifocal demyelination of the central nervous system and by peripheral adrenal insufficiency (Addison disease). It results in mental deterioration, corticospinal tract dysfunction, and cortical blindness. Different clinical manifestations exist like: cerebral childhood ALD (CALD), adult cerebral ALD (ACALD), adrenomyeloneuropathy (AMN) and 'Addison disease only' (ADO) phenotype.
    Note=The promoter region of ABCD1 is deleted in the chromosome Xq28 deletion syndrome which involves ABCD1 and the neighboring gene BCAP31.
  • Sequence similaritiesBelongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
    Contains 1 ABC transmembrane type-1 domain.
    Contains 1 ABC transporter domain.
  • Cellular localizationPeroxisome membrane.

    • Target information above from: UniProt accession P33897 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for ABCD1 protein (His-DHFR tag) (ab127510)

    ab127510 has not yet been referenced specifically in any publications.

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