ABCE1 antibody (ab4688)

Product Name 

ABCE1 antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to ABCE1

Immunogen 

Fusion protein, corresponding to amino acids 1-119 of Human ABCE 1.

Reacts with 
(species key)

Hu

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
WB: 1/250 - 1/1000. Detects a band of approximately 68 kDa.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

HeLa and 293 cell lysates.

Cellular localization 

Cytoplasm. Mitochondrion. Localized to clusters of virus formation at the plasma membrane.

Research areas 

Immunology >> Immune System Diseases >> Antiviral Signaling
Signal Transduction >> Protein Trafficking >> Chaperones >> Other Chaperones
Signal Transduction >> Metabolism >> Plasma Membrane >> ATPases
Signal Transduction >> Adapters >> Transmembrane

Relevance 

ABCE1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. It is alternatively referred to as the RNase L inhibitor as it functions to block the activity of ribonuclease L(referenced from entrez gene).

ABCE 1 is a member of the ABC Transporter superfamily, although it is not a membrane transporter. It is cytosolically expressed and inhibits the RNaseL protein. Recently, it has been found to be essential for the assembly of immature immunodeficiency virus capsids.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.05% Sodium Azide

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.200 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

References for ABCE1 antibody (ab4688)

  This product has been used in:

Le Roy F et al. Regulation of mitochondrial mRNA stability by RNase L is translation-dependent and controls IFNalpha-induced apoptosis. Cell Death Differ 14:1406-13 (2007). WB; Human. PubMed: 17431428

If you publish research using ab4688 please let us know so that we can cite the reference on this datasheet.

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