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Overview

  • Product nameABCE1 protein (Tagged)See all ABCE1 proteins and peptides ...
  • Protein descriptionRecombinant full length Human ABCE1 (amino acids 1-599) with N terminal proprietary tag; Predicted MW 93.7 kDa (inclusive of tag).
  • Uniprot accessionP61221
  • Molecular weight93.700kDa inclusive of tags
  • Protein length599 amino acids
  • Expression hostWheat germ

    • Properties

  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl
  • Concentration information loading...
  • Additional notesProtein concentration is above or equal to 0.05 µg/µl.
  • Sequence notesMADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIE VTPQSKIAWISETLCIGCGICIKKCPFGALSIVNLPSNLE KETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTAL KILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKIL EDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIV CQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMF DEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLD YLSDFICCLYGVPSAYGVVTMPFSVREGINIFLDGYVPTE NLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEF ELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDE GGEVPVLNVSYKPQKISPKSTGSVRQLLHEKIRDAYTHPQ FVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPA DVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEH DFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLS QLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab131962 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA ELISA: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    WB WB: Use at an assay dependent concentration.

    Protein info

    • Alternative names
        2' 5' oligoadenylate binding protein2''-5''-oligoadenylate-binding protein2'5' oligoadenylate binding protein
        ABC 38ABC38ABCE 1ABCE1ABCE1_HUMANATP binding cassette sub family E (OABP) member 1ATP binding cassette sub family E member 1ATP-binding cassette sub-family E member 1HuHP 68HuHP68OABPRibonuclease 4 inhibitorRibonuclease L (2' 5' oligoisoadenylate synthetase dependent) inhibitorRibonuclease L (2'5' oligoisoadenylate synthetase dependent) inhibitorRibonuclease L inhibitorRLIRNase L inhibitorRNASEL1RNASELIRNS 4IRNS4I
      see all
  • FunctionAntagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
  • Sequence similaritiesBelongs to the ABC transporter superfamily. ABCE family.
    Contains 2 4Fe-4S ferredoxin-type domains.
    Contains 2 ABC transporter domains.
  • Cellular localizationCytoplasm. Mitochondrion. Localized to clusters of virus formation at the plasma membrane.

    • Target information above from: UniProt accession P61221 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    ABCE1 protein (Tagged) images

    • SDS-PAGE - ABCE1 protein (Tagged) (ab131962)
      SDS-PAGE - ABCE1 protein (Tagged) (ab131962)
      12.5% SDS-PAGE analysis of ab131962 stained with Coomassie Blue.

    References for ABCE1 protein (Tagged) (ab131962)

    ab131962 has not yet been referenced specifically in any publications.

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