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Anti-ABCG1 antibody [EP1366Y] (ab52617)

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Overview

Product name

Anti-ABCG1 antibody [EP1366Y]
See all ABCG1 products (3) ...

Description

Rabbit monoclonal [EP1366Y] to ABCG1

Tested applications

WB, IHC-P, ICCmore details

Cross reactivity

Reacts with

Mouse, Rat, Cow, Human

Immunogen

A synthetic peptide corresponding to residues on human ABCG1.

Positive control

HUVEC cell lysate, human cervical carcinoma.

General notes

Produced under U.S. Patent No. 5,675,063.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.01% Sodium Azide
Constituents: 40% Glycerol, 0.05% BSA, Tissue culture supernatant, 0.15M Sodium chloride, 50mM Tris glycine, pH 7.4

Purity

Tissue culture supernatant

Clonality

Monoclonal

Clone number

EP1366Y

Isotype

IgG

Research areas

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Cardiovascular >> Atherosclerosis >> Lipid transport
Cardiovascular >> Atherosclerosis >> Lipoprotein metabolism
Signal Transduction >> Metabolism >> Lipid metabolism
Cardiovascular >> Lipids / Lipoproteins >> Lipoproteins/Apolipoproteins
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism
Neuroscience >> Cell Type Marker >> Glia marker >> Astrocyte marker

  • Western blot - ABCG1 antibody [EP1366Y] (ab52617)Western blot - ABCG1 antibody [EP1366Y] (ab52617) image (enlarge)

  • Immunohistochemistry (Paraffin-embedded sections) - ABCG1 antibody [EP1366Y] (ab52617)Immunohistochemistry (Paraffin-embedded sections) - ABCG1 antibody [EP1366Y] (ab52617) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab52617 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

Is unsuitable for ,Flow Cyt or IP.

Target

Function

Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.

Tissue specificity

Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Contains 1 ABC transmembrane type-2 domain.
Contains 1 ABC transporter domain.

Cellular localization

Endoplasmic reticulum membrane. Golgi apparatus membrane. Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.

Target information above from: UniProt accessionP45844 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • ABC transporter 8 antibody
  • Abc8 antibody
  • ABCG1 antibody
  • ABCG1_HUMAN antibody
  • ATP-binding cassette sub family G member 1 antibody
  • ATP-binding cassette sub-family G member 1 antibody
  • ATP-binding cassette transporter 8 antibody
  • ATP-binding cassette transporter member 1 of subfamily G antibody
  • ATP-binding cassette, sub family G WHITE member 1 antibody
  • homolog of Drosophila white antibody
  • MGC34313 antibody
  • White protein homolog antibody
  • White protein homolog ATP binding cassette transporter 8 antibody
  • WHITE1 antibody
  • wht1 antibody
see all

Database links

see all

Anti-ABCG1 antibody [EP1366Y] images:

  Western blot - ABCG1 antibody [EP1366Y] (ab52617)

Western blot - ABCG1 antibody [EP1366Y] (ab52617)

Anti-ABCG1 antibody [EP1366Y] (ab52617) at 1/2000 dilution + HUVEC cell lysate at 10 µg

Secondary
Goat anti-rabbit HRP antiibody at 1/2000 dilution

Predicted band size : 75 kDa
Observed band size : 110 kDa (why is the actual band size different from the predicted?)

  Immunohistochemistry (Paraffin-embedded sections) - ABCG1 antibody [EP1366Y] (ab52617)

Immunohistochemistry (Paraffin-embedded sections) - ABCG1 antibody [EP1366Y] (ab52617)

Ab52617 at 1/50 dilution staining human cervical carcinoma tissue; paraffin embedded.

References for Anti-ABCG1 antibody [EP1366Y] (ab52617)

This product has been referenced in:

  • Mukhamedova Net al. Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo. J Lipid Res : (2008). WB; Human.Read more (PubMed: 18622028) »
  • Terasaka Net al. ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. J Clin Invest 118:3701-13 (2008). WB; Human.Read more (PubMed: 18924609) »

See all 2 publications for this product

Publishing research using ab52617? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"