ABCG1 antibody (HRP) (ab81951)

Product Name 

ABCG1 antibody (HRP)

Product type 

Primary antibodies

Description 

Rabbit polyclonal to ABCG1 (HRP)

Immunogen 

A synthetic peptide corresponding to an internal region of Human ABCG1 between residues 300-400.

Reacts with 
(species key)

Hu, Ms

Tested applications 
(see key)

IHC-P, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
IHC-P: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Detects a band of approximately 76 kDa (predicted molecular weight: 76 kDa).

Is unsuitable for IP.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Mouse peritoneal macrophages treated with 22-R-hydroxycholesterol and T0901317.

Cellular localization 

Endoplasmic reticulum membrane and Golgi Apparatus membrane; Multi-pass membrane protein.

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Cardiovascular >> Atherosclerosis >> Lipid transport
Cardiovascular >> Atherosclerosis >> Lipoprotein metabolism
Signal Transduction >> Metabolism >> Lipid metabolism

Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism
Neuroscience >> Cell Type Marker >> Glia marker >> Astrocyte marker

Relevance 

ABCG1, one of five members of the ABCG subfamily, belongs to the large family of ATP-binding cassette (ABC) transporters. The protein is expressed in the plasma membrane of adipocytes, macrophages and other cell types. In these cells, ABCG1 facilitates cholesterol efflux to apoAI and/or high-density lipoprotein (HDL). The function of ABCG1 is linked to both obesity and atherosclerosis. First, studies in Abcg1 knockout mice showed that the gene deletion resulted in a significantly reduced size of fat cells. Second, the activation of ABCG1 expression promoted atherosclerotic lesion development while inactivation of macrophage ABCG1 expression reduced it in proatherogenic mice. In addition, ABCG1 plays a key role in lipoprotein formation by glia.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: None
Constituents: Tris citrate/phosphate, pH 7-8

Form 

Liquid

Conjugation 

Horse Radish Peroxidase

Storage instructions 

Store at +4°C. Do not freeze.

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