Anti-ABCG5 antibody - N-terminal (ab198737)

Overview

  • Product name
    Anti-ABCG5 antibody - N-terminal
    See all ABCG5 primary antibodies
  • Description
    Rabbit polyclonal to ABCG5 - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human ABCG5 (N terminal). NP_071881.
    Database link: Q9H222

  • Positive control
    • Human liver cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab198737 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.

Target

  • Function
    Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
  • Tissue specificity
    Strongly expressed in the liver, lower levels in the small intestine and colon.
  • Involvement in disease
    Defects in ABCG5 are a cause of sitosterolemia (STSL) [MIM:210250]; also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease.
  • Sequence similarities
    Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
    Contains 1 ABC transmembrane type-2 domain.
    Contains 1 ABC transporter domain.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Abcg5 antibody
    • ABCG5_HUMAN antibody
    • ATP binding cassette sub family G (WHITE) member 5 (sterolin 1) antibody
    • ATP binding cassette sub family G member 5 antibody
    • ATP-binding cassette sub-family G member 5 antibody
    • ATP-binding cassette, sub-family G (WHITE), member 5 antibody
    • Sterolin 1 antibody
    • Sterolin-1 antibody
    • STSL antibody
    see all

Images

  • Immunohistochemical analysis of Paraffin-embedded Human liver cancer tissue labeling ABCG5 with ab198737 at 1/20 dilution.

References

ab198737 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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