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- ABCG8 antibody (ab5362)
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Product Name
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ABCG8 antibody
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See all ABCG8 antibodies (2)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to ABCG8
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Immunogen
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N-terminal synthetic peptide (Human).
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Reacts with
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Hu
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Does not react with
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Ms
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Tested applications
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WB
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Abreviews
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Application notes
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Recommended dilutions
WB: 1/500. Predicted molecular weight: 81 kDa.
Is unsuitable for IHC.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
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mouse liver microsomes expressing human ABCG8 transgene
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Cellular localization
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Integral membrane protein; multi-pass membrane protein.
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Research areas
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Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Cardiovascular >> Atherosclerosis >> Lipid transport
Signal Transduction >> Metabolism >> Lipid metabolism
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism
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Relevance
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ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. ABCG8, expressed at high levels in the liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols. The mutated form of this transporter can lead to sterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessive disorder, characterized by hyperabsorption of sterols and the inability to excrete sterols into bile.
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. ABCG8, expressed at high levels in the liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols. The mutated form of this transporter can lead to sterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessive disorder, characterized by hyperabsorption of sterols and the inability to excrete sterols into bile.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: None
Constituents: PBS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this ABCG8 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for ABCG8 antibody images, references, products related to ab5362 and other tools.
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ABCG8 antibody images:
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 - ABCG8 antibody (ab5362)
Predicted band size : 81 kDa
ab5362 at a 1/500 dilution staining approximately 81 kDa human ABCG 8 by Western blot (ECL).
A = Mouse liver microsomes from G5/8 knockout.
B = Wild type.
C = Mice expressing G5/8 transgenes.
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Search PubMed (MEDLINE) for references to ABCG8
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ABCG8 antibody - more information
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Customer reviews (feedback) regarding ABCG8 antibody |
Customer FAQs regarding ABCG8 antibody |
Protocols for ABCG8 antibody |
Price and availability of products related to ABCG8 antibody |
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ABCG8 antibody - related products:
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ABCG8 antibody - other tools:
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Contact Abcam with a Technical Enquiry about ABCG8 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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