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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Direct Chemical Reversal
Overview
Product name
ABH1 peptide
Protein description
Synthetic peptide derived from within residues 350 to the C-terminus of Human ABH1.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab18525 - ABH1 antibody.
Protein length
389 amino acids
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Information available upon request.
Concentration
Concentration information loading...
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Direct Chemical Reversal
Applications
Application notes
This peptide can be used with studies using ab18525.
Protein info
Function
Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.
Tissue specificity
Ubiquitous.
Sequence similarities
Belongs to the alkB family.
Contains 1 Fe2OG dioxygenase domain.
Cellular localization
Mitochondrion. Nucleus. Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli.
Target information above from: UniProt accessionQ13686
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for ABH1 peptide (ab19826)
ab19826 has not yet been referenced specifically in any publications.
Publishing research using ab19826? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"