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Overview

  • Product nameABH1 protein (Tagged)See all ABH1 proteins and peptides ...
  • Protein descriptionRecombinant full length Human ABH1 (amino acids 1-389) with N terminal proprietary tag; Predicted MWt 68.42 kDa inclusive of tag.
  • Uniprot accessionQ13686
  • Molecular weight68.420kDa inclusive of tags
  • Protein length389 amino acids
  • Expression hostWheat germ

    • Properties

  • E.C. Number1.14.11.-
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl
  • Concentration information loading...
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Sequence notesMGKMAAAVGSVATLATEPGEDAFRKLFRFYRQSRPGTADL EGVIDFSAAHAARGKGPGAQKVIKSQLNVSSVSEQNAYRA GLQPVSKWQAYGLKGYPGFIFIPNPFLPGYQWHWVKQCLK LYSQKPNVCNLDKHMSKEETQDLWEQSKEFLRYKEATKRR PRSLLEKLRWVTVGYHYNWDSKKYSADHYTPFPSDLGFLS EQVAAACGFEDFRAEAGILNYYRLDSTLGIHVDRSELDHS KPLLSFSFGQSAIFLLGGLQRDEAPTAMFMHSGDIMIMSG FSRLLNHAVPRVLPNPEGEGLPHCLEAPLPAVLPRDSMVE PCSMEDWQVCASYLKTARVNMTVRQVLATDQNFPLEPIED EKRDISTEGFCHLDDQNSEVKRARINPHS
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab132191 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA ELISA: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    WB WB: Use at an assay dependent concentration.
  • Application notesThis peptide can be used with studies using ab166726 and ab169689.

    • Protein info

    • Alternative names
        ABHABH1alkB
        AlkB, alkylation repair homolog 1 (E. coli)ALKB1_HUMANALKBHALKBH1Alkylated DNA repair protein alkB homolog 1Alkylation repair homolog 1Alkylation repair, alkB homologAlpha-ketoglutarate-dependent dioxygenase ABH1DNA lyase ABH1DNA oxidative demethylase ALKBH1hABH
      see all
  • FunctionDioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.
  • Tissue specificityUbiquitous.
  • Sequence similaritiesBelongs to the alkB family.
    Contains 1 Fe2OG dioxygenase domain.
  • Cellular localizationMitochondrion. Nucleus. Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli.

    • Target information above from: UniProt accession Q13686 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    ABH1 protein (Tagged) images

    • SDS-PAGE - ABH1 protein (Tagged) (ab132191)
      SDS-PAGE - ABH1 protein (Tagged) (ab132191)
      12.5% SDS-PAGE analysis of ab132191 stained with Coomassie Blue.

    References for ABH1 protein (Tagged) (ab132191)

    ab132191 has not yet been referenced specifically in any publications.

    Publishing research using ab132191 ? Please let us know so that we can cite the reference in this datasheet

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