Overview
Product nameABI2 protein (His tag)
Protein descriptionRecombinant fragment corresponding to amino acids 29-268 of Human ABI2 with N terminal His tag; Predicted MWt 27 kDa (BC001439).
Uniprot accessionQ9NYB9-2
Molecular weight27kDa inclusive of tags
Protein length240 amino acids
Expression hostE. coli
Properties
Purification notesPurity determined to be >95% by SDS-PAGE.
FormLyophilised:Reconstitute with water to desired concentration.
Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferConstituents: 0.32% Tris HCl, 0.58% Sodium chloride
Concentration information loading...
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab127336
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|
Application
|
Notes |
| SDS-PAGE |
SDS-PAGE: Use at an assay dependent dilution. |
Protein info
-
Alternative names
Abelson interactor 2ABI 2ABI2B
Abl binding protein 3Abl interacting protein 1 (SH3 containing protein)Abl interactor 2Abl interactor protein 2bAblBP3AIP 1Arg binding protein 1Arg protein tyrosine kinase binding proteinArgBP1ARGBPIAArgBPIBOTTHUMP00000163783OTTHUMP00000163784OTTHUMP00000206182OTTHUMP00000206183OTTHUMP00000206184OTTHUMP00000206185SSH3BP2
see all
RelevanceABI2 (Abelson interactor 2) belongs to the ABI family. The Abelson interactors are among a group of proteins that interact with Abl tyrosine kinase, a non-receptor tyrosine kinase whose activation results in the regulation of cytoskeleton function, cell growth and apoptosis in response to a variety of biological stimuli.
ABI2 may act in regulation of cell growth and transformation by interacting tyrosine kinases ABL1 and/or ABL2 and may be involved in cytoskeletal reorganization and regulation of the ABL1/c-Abl-mediated phosphorylation of MENA. ABI2 is also known to be a tumor suppressor and a cell migration inhibitor.
Cellular localizationIsoform 1: Cell projection, lamellipodium and filopodium. Cytoplasm, cytoskeleton. Note: Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips
References for ABI2 protein (His tag) (ab127336)
ab127336
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
