Anti-ACAD8 antibody (ab102810)

Overview

• Product nameAnti-ACAD8 antibodySee all ACAD8 primary antibodies ...
• Description
  Rabbit polyclonal to ACAD8
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Mouse, Human
  
• Immunogen

  Synthetic peptide corresponding to a region within internal sequence amino acids 125-154 of Human ACAD8 (UniProt ID: Q9UKU7) conjugated to KLH.

• Positive controlMouse stomach tissue lysates

Properties

• FormLiquid
• Storage instructionsStore at 4°C (up to 6 months). For long term storage store at -20°C
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab102810 is purified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Signal Transduction
  • Metabolism
  • Mitochondrial

Applications

Target

• FunctionHas very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex.
• Tissue specificityDetected at comparable levels in all tissues examined (heart, lung, brain, skeletal muscle, pancreas and placenta). Weakly expressed in liver and kidney.
• PathwayAmino-acid degradation; L-valine degradation.
• Involvement in diseaseDefects in ACAD8 are the cause of isobutyryl-CoA dehydrogenase deficiency (IBDD) [MIM:611283]. The symptoms of IBDD generally appear until late in infancy or in childhood and can include poor feeding and growth (failure to thrive), a weakened and enlarged heart (dilated cardiomyopathy), seizures, and low numbers of red blood cells (anemia).
• Sequence similaritiesBelongs to the acyl-CoA dehydrogenase family.
• Cellular localizationMitochondrion.

Target information above from: UniProt accession Q9UKU7 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 27034 Human
  • Entrez Gene: 66948 Mouse
  • Omim: 604773 Human
  • SwissProt: Q9UKU7 Human
  • SwissProt: Q9D7B6 Mouse
  • Unigene: 14791 Human
  • Unigene: 289244 Mouse

• Alternative names
  ACAD 8 antibodyACAD-8 antibodyACAD8 antibody

  ACAD8_HUMAN antibodyActivator-recruited cofactor 42 kDa component antibodyAcyl CoA dehydrogenase family member 8 antibodyAcyl Coenzyme A dehydrogenase family member 8 antibodyAcyl-CoA dehydrogenase family member 8 antibodyARC42 antibodyFLJ22590 antibodyIBD antibodyIsobutyryl-CoA dehydrogenase antibodyIsobutyryl-CoA dehydrogenase, mitochondrial antibodymitochondrial antibody

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Anti-ACAD8 antibody images

• 

  Western blot - ACAD8 antibody (ab102810)
  Anti-ACAD8 antibody (ab102810) at 1/100 dilution + Mouse stomach tissue lysates at 35 µg
  
  Predicted band size : 45 kDa