Overview

  • Product nameAnti-ACAD8 antibodySee all ACAD8 primary antibodies ...
  • Description
    Rabbit polyclonal to ACAD8
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 125-154 of Human ACAD8 (UniProt ID: Q9UKU7) conjugated to KLH.

  • Positive control
    • Mouse stomach tissue lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab102810 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB 1/100 - 1/500. Predicted molecular weight: 45 kDa.

Target

  • FunctionHas very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex.
  • Tissue specificityDetected at comparable levels in all tissues examined (heart, lung, brain, skeletal muscle, pancreas and placenta). Weakly expressed in liver and kidney.
  • PathwayAmino-acid degradation; L-valine degradation.
  • Involvement in diseaseDefects in ACAD8 are the cause of isobutyryl-CoA dehydrogenase deficiency (IBDD) [MIM:611283]. The symptoms of IBDD generally appear until late in infancy or in childhood and can include poor feeding and growth (failure to thrive), a weakened and enlarged heart (dilated cardiomyopathy), seizures, and low numbers of red blood cells (anemia).
  • Sequence similaritiesBelongs to the acyl-CoA dehydrogenase family.
  • Cellular localizationMitochondrion.
  • Target information above from: UniProt accession Q9UKU7 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • ACAD 8 antibody
    • ACAD-8 antibody
    • ACAD8 antibody
    • ACAD8_HUMAN antibody
    • Activator-recruited cofactor 42 kDa component antibody
    • Acyl CoA dehydrogenase family member 8 antibody
    • Acyl Coenzyme A dehydrogenase family member 8 antibody
    • Acyl-CoA dehydrogenase family member 8 antibody
    • ARC42 antibody
    • FLJ22590 antibody
    • IBD antibody
    • Isobutyryl-CoA dehydrogenase antibody
    • Isobutyryl-CoA dehydrogenase, mitochondrial antibody
    • mitochondrial antibody
    see all

Anti-ACAD8 antibody images

  • Anti-ACAD8 antibody (ab102810) at 1/100 dilution + Mouse stomach tissue lysates at 35 µg

    Predicted band size : 45 kDa

References for Anti-ACAD8 antibody (ab102810)

ab102810 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab102810.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"