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Overview

  • Product nameACADL proteinSee all ACADL proteins and peptides ...
  • Protein descriptionRecombinant full length protein, (amino acids 31-430) of Human ACADL with N terminal His tag; 421 amino acids, 46.7 kDa inclusive of tag (P28330).
  • Uniprot accessionP28330
  • Molecular weight46.700kDa inclusive of tags
  • Protein length400 amino acids
  • Expression hostE. coli

    • Properties

  • Purity> 85 % by SDS-PAGE
  • Purification notes> 85 % by SDS - PAGE. ab113579 is purified using conventional chromatography techniques.
  • Mass spectrometryMALDI-TOF
  • E.C. Number1.3.99.13
  • FormLiquid
  • Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol, 0.02% DTT, 0.88% Sodium chloride
  • Concentration information loading...
  • SequenceMGSSHHHHHHSSGLVPRGSHMGGEERLETPSAKKLTDIGI RRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREV WEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAYSNC SGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGA IAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSL SDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLH KMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELP QERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQT VQHKLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAK YWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQP IYGGTNEIMKELIAREIVFDK
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab113579 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
    MS MS: Use at an assay dependent concentration.

    Protein info

    • Alternative names
        ACAD4ACADLACADL_HUMAN
        Acyl Coenzyme A dehydrogenase long chainAcyl-CoA dehydrogenase long chainFLJ94052LCADLong chain acyl CoA dehydrogenaseLong-chain specific acyl-CoA dehydrogenaseLong-chain specific acyl-CoA dehydrogenase, mitochondrialmitochondrial
      see all
  • PathwayLipid metabolism; mitochondrial fatty acid beta-oxidation.
  • Involvement in diseaseDefects in ACADL are a cause of acyl-CoA dehydrogenase very long-chain deficiency (ACADVLD) [MIM:201475]. An inborn error of mitochondrial fatty acid beta-oxidation which leads to impaired long-chain fatty acid beta-oxidation. It is clinically heterogeneous, with three major phenotypes: a severe childhood form characterized by early onset, high mortality and high incidence of cardiomyopathy; a milder childhood form with later onset, characterized by hypoketotic hypoglycemia, low mortality and rare cardiomyopathy; an adult form, with isolated skeletal muscle involvement, rhabdomyolysis and myoglobinuria, usually triggered by exercise or fasting.
  • Sequence similaritiesBelongs to the acyl-CoA dehydrogenase family.
  • Cellular localizationMitochondrion matrix.

    • Target information above from: UniProt accession P28330 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    ACADL protein images

    • SDS-PAGE - ACADL protein (ab113579)
      SDS-PAGE - ACADL protein (ab113579)
      15% SDS-PAGE showing ab113579 (3µg).

    References for ACADL protein (ab113579)

    ab113579 has not yet been referenced specifically in any publications.

    Publishing research using ab113579 ? Please let us know so that we can cite the reference in this datasheet

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