Overview

  • Product name
  • Description
    Rabbit polyclonal to ACADSB
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-226 of Human ACADSB (Uniprot ID: P45954).

  • Positive control
    • HepG2 whole cell lysate; Human hepatoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab154495 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000 - 1/20000. Predicted molecular weight: 47 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function
    Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent.
  • Tissue specificity
    Ubiquitous.
  • Pathway
    Lipid metabolism; mitochondrial fatty acid beta-oxidation.
  • Involvement in disease
    Defects in ACADSB are the cause of short/branched-chain acyl-CoA dehydrogenase deficiency (SBCADD) [MIM:610006]; also known as 2-methylbutyryl-CoA dehydrogenase deficiency or 2-methylbutyryl glycinuria. SBCADD is an autosomal recessive disorder and consists of a defect in catabolism of L-isoleucine which is characterized by an increase of 2-methylbutyrylglycine and 2-methylbutyrylcarnitine in blood and urine. Affected individuals have seizures and psychomotor delay as the main clinical features.
  • Sequence similarities
    Belongs to the acyl-CoA dehydrogenase family.
  • Cellular localization
    Mitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2 MEBCAD antibody
    • 2 methyl branched chain acyl CoA dehydrogenase antibody
    • 2 methylbutyryl CoA dehydrogenase antibody
    • 2 methylbutyryl coenzyme A dehydrogenase antibody
    • 2-MEBCAD antibody
    • 2-methyl branched chain acyl-CoA dehydrogenase antibody
    • 2-methylbutyryl-CoA dehydrogenase antibody
    • 2-methylbutyryl-coenzyme A dehydrogenase antibody
    • ACAD7 antibody
    • ACADSB antibody
    • ACDSB_HUMAN antibody
    • acyl CoA dehydrogenase, short/branched chain antibody
    • acyl Coenzyme A dehydrogenase short branched chain antibody
    • mitochondrial antibody
    • OTTHUMP00000020685 antibody
    • OTTHUMP00000046795 antibody
    • SBCAD antibody
    • Short/branched chain specific acyl-CoA dehydrogenase antibody
    • short/branched chain specific acyl-CoA dehydrogenase, mitochondrial antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human Hepatoma tissue, labeling ACADSB with ab154495 at 1/500 dilution.
  • Anti-ACADSB antibody (ab154495) at 1/10000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size: 47 kDa



    10% SDS PAGE

References

ab154495 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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