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Overview

  • Product nameACCN1 peptide
  • Protein descriptionA synthetic peptide from the extracellular domain of Mouse ACCN1, conjugated to an immunogenic carrier protein. The antigen is homologous in human and rat.

    • Properties

  • FormLyophilised
  • Storage instructionsShipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab129538 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Blocking BL: Use at an assay dependent concentration.
  • Application notesThis peptide can be used with studies using ab77384.

    • Protein info

    • Alternative names
        ACCNACCN1ACCN1_HUMAN
        Acid sensing ion channel 2Acid-sensing ion channel 2Amiloride sensitive brain sodium channelAmiloride sensitive cation channel 1 neuronalAmiloride sensitive cation channel 1 neuronal (degenerin)Amiloride-sensitive brain sodium channelAmiloride-sensitive cation channel 1, neuronalAmiloride-sensitive cation channel neuronal 1ASIC2ASIC2aBNaC1BNC1Brain sodium channel 1DegenerinhBNaC1Mammalian degenerin homologMDEGNeuronal amiloride sensitive cation channel 1
      see all
  • FunctionCation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
  • Tissue specificityBrain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
  • Sequence similaritiesBelongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN1 subfamily.
  • Cellular localizationCell membrane. Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.

    • Target information above from: UniProt accession Q16515 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for ACCN1 peptide (ab129538)

    ab129538 has not yet been referenced specifically in any publications.

    Publishing research using ab129538 ? Please let us know so that we can cite the reference in this datasheet

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