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Overview

  • Product nameACOX1 protein
  • Protein descriptionRecombinant full length (aa 1-660) Human ACOX1 (Q15067) with N-Terminal proprietary tag. Mol Wt 98.71 kDa inclusive of tag.
  • Uniprot accessionQ15067
  • Molecular weight98.710kDa inclusive of tags
  • Protein length660 amino acids
  • Expression hostWheat germ

    • Properties

  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl
  • Concentration information loading...
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Sequence notesMNPDLRRERDSASFNPELLTHILDGSPEKTRRRREIENMI LNDPDFQHEDLNFLTRSQRYEVAVRKSAIMVKKMREFGIA DPDEIMWFKNFVHRGRPEPLDLHLGMFLPTLLHQATAEQQ ERFFMPAWNLEIIGTYAQTEMGHGTHLRGLETIATYDPET QEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITKGKCY GLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEIDNGYL KMDNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVF VRSFLVGEAARALSKACTIAIRYSAVRHQSEMKPGEPEPQ ILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIG QGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHG YSHCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYD QVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSP ESLTEAYKLRAARLVEIAAKNLQKEVIHRKSKEVAWNLTS VDLVRASEAHCHYVVVKLFSEKLLKIQDKAIQAVLRSLCL LYSLYGISQNAGDFLQGSIMTEPQITQVNQRVKELLTLIR SDAVALVDAFDFQDVTLGSVLGRYDGNVYENLFEWAKNSP LNKAEVHESYKHLKSLQSKL
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab114556 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA ELISA: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    WB WB: Use at an assay dependent concentration.

    Protein info

    • Alternative names
        ACOX1ACOX1_HUMANAOX
        EC 1.3.3.6Palmitoyl CoA oxidasePalmitoyl-CoA oxidasePeroxisomal acyl coenzyme A oxidase 1Peroxisomal acyl-coenzyme A oxidase 1SCOXStraight chain acyl CoA oxidaseStraight-chain acyl-CoA oxidase
      see all
  • FunctionCatalyzes the desaturation of very long chain acyl-CoAs to 2-trans-enoyl-CoAs.
  • PathwayLipid metabolism; peroxisomal fatty acid beta-oxidation.
  • Involvement in diseaseDefects in ACOX1 are the cause of adrenoleukodystrophy pseudoneonatal (Pseudo-NALD) [MIM:264470]; also known as peroxisomal acyl-CoA oxidase deficiency. Pseudo-NALD is a peroxisomal single-enzyme disorder. Clinical features include mental retardation, leukodystrophy, seizures, mild hepatomegaly, hearing deficit. Pseudo-NALD is characterized by increased plasma levels of very-long chain fatty cids, due to decreased or absent peroxisome acyl-CoA oxidase activity. Peroxisomes are intact and functioning.
  • Sequence similaritiesBelongs to the acyl-CoA oxidase family.
  • Cellular localizationPeroxisome.

    • Target information above from: UniProt accession Q15067 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    ACOX1 protein images

    • SDS-PAGE - ACOX1 protein (ab114556)
      SDS-PAGE - ACOX1 protein (ab114556)
      12.5% SDS-PAGE Stained with Coomassie Blue

    References for ACOX1 protein (ab114556)

    ab114556 has not yet been referenced specifically in any publications.

    Publishing research using ab114556 ? Please let us know so that we can cite the reference in this datasheet

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