![Western blot - ACVRL1 antibody [EPR4074] (ab108207) image](#ACVRL1-Primary-antibodies-ab108207-2.JPG)
Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Related products
- Lysates
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Overview
Product name
Anti-ACVRL1 antibody [EPR4074]
See all ACVRL1 products (7) ...
Description
Rabbit monoclonal [EPR4074] to ACVRL1
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide (Human)
Positive control
JAR, Daudi or Jurkat cell lysate
General notes
Produced under U.S. Patent No. 5,675,063.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purity
Tissue culture supernatant
Clonality
Monoclonal
Clone number
EPR4074
Isotype
IgG1
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Amino acid metabolism
Cardiovascular >> Vasculature >> Endothelium
Signal Transduction >> Growth Factors/Hormones >> TGF
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Signal Transduction >> Metabolism >> Amino Acids
Cardiovascular >> Angiogenesis >> Growth Factors >> TGF
-
Western blot - ACVRL1 antibody [EPR4074] (ab108207)
![Western blot - ACVRL1 antibody [EPR4074] (ab108207) image](/ps/datasheet/images/108/ab108207/ACVRL1-Primary-antibodies-ab108207-2.JPG)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab108207 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000 - 1/10000. Predicted molecular weight: 56 kDa.
Target
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
Involvement in disease
Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.
Cellular localization
Membrane.
Target information above from: UniProt accessionP37023
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Activin A receptor antibody
- Activin A receptor antibody
- Activin A receptor type II like 1 antibody
see all
Database links
- Entrez Gene: 94 Human
- Entrez Gene: 11482 Mouse
- Entrez Gene: 25237 Rat
- Omim: 601284 Human
- SwissProt: P37023 Human
- SwissProt: Q61288 Mouse
- SwissProt: P80203 Rat
- Unigene: 591026 Human
see all
Anti-ACVRL1 antibody [EPR4074] images:
Western blot - ACVRL1 antibody [EPR4074] (ab108207)
All lanes : Anti-ACVRL1 antibody [EPR4074] (ab108207) at 1/1000 dilution
Lane 1 : JAR cell lysate
Lane 2 : Daudi cell lysate
Lane 3 : Jurkat cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size : 56 kDa
References for Anti-ACVRL1 antibody [EPR4074] (ab108207)
ab108207 has not yet been referenced specifically in any publications.
Publishing research using ab108207? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"