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Product Name
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ACVRL1 antibody [RM0015-1B03]
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See all ACVRL1 antibodies (5)...
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Product type
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Primary antibodies
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Description
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Rat monoclonal [RM0015-1B03] to ACVRL1
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Immunogen
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Purified ALK1 extracellular domain (Mouse)
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Reacts with
(species key)
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Ms
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Specificity
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ab51656 antibody recognizes mouse ACVRL1.
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Tested applications
(see key)
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IHC-Fr, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-Fr: Use at an assay dependent dilution.
WB: 1/200. Predicted molecular weight: 56 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; single-pass type I membrane protein
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Research areas
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Cardiovascular >> Vasculature >> Endothelium
Signal Transduction >> Growth Factors/Hormones >> TGF
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Signal Transduction >> Metabolism >> Amino Acids
Cardiovascular >> Angiogenesis >> Growth Factors >> TGF
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Relevance
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Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.
With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
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Database links
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The links below go to external sites and will open in a new browser window Entrez Gene | | 11482 (Mouse)
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Raised in
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Rat
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Clonality
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Monoclonal
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Clone number
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RM0015-1B03
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Isotype
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IgG2a
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
Constituents: PBS
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Purification notes
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ab51656 is produced from a hybridoma, the IgG fraction of the culture supernatant was purified by Protein G affinity chromatography and lyophilized.
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Form
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Liquid
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Concentration
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0.200 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this ACVRL1 antibody [RM0015-1B03] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to ACVRL1
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ACVRL1 antibody [RM0015-1B03] - more information
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