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Products:Cardiovascular >> Angiogenesis >> Growth Factors >> TGF
Overview
Product name
Anti-ACVRL1 antibody [RM0015-1B03]
See all ACVRL1 products (7) ...
Description
Rat monoclonal [RM0015-1B03] to ACVRL1
Specificity
ab51656 antibody recognizes mouse ACVRL1.
Tested applications
WB, IHC-Frmore details
Cross reactivity
Reacts with
Mouse
Immunogen
Purified ALK1 extracellular domain (Mouse)
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Purification notes
ab51656 is produced from a hybridoma, the IgG fraction of the culture supernatant was purified by Protein G affinity chromatography and lyophilized.
Clonality
Monoclonal
Clone number
RM0015-1B03
Isotype
IgG2a
Research areas
Cardiovascular >> Vasculature >> Endothelium
Signal Transduction >> Growth Factors/Hormones >> TGF
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Signal Transduction >> Metabolism >> Amino Acids
Cardiovascular >> Angiogenesis >> Growth Factors >> TGF
Applications
Show applications key
Our Abpromise guarantee covers the use of ab51656 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/200Predicted molecular weight: 56 kDa.
IHC-Fr: Use at an assay dependent dilution.
Target
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
Involvement in disease
Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.
Cellular localization
Membrane.
Target information above from: UniProt accessionP37023
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Activin A receptor antibody
- Activin A receptor type II like 1 antibody
- Activin receptor like kinase 1 antibody
see all
Database links
- Entrez Gene: 11482 Mouse
- SwissProt: Q61288 Mouse
- Unigene: 279542 Mouse
References for Anti-ACVRL1 antibody [RM0015-1B03] (ab51656)
ab51656 has not yet been referenced specifically in any publications.
Publishing research using ab51656? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"