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Anti-ACVRL1 antibody (ab37807)

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1 question for ab37807

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Question 1

Wednesday 28-December-2011

I would like to order Anti ACVRL antibody #37807 from abcam for staining tumour samples. Since ALK is a endothelial specific marker...I should see only blood vessels positive, however, in the data sheet of your product you have photographs showing all the cells positive in a carcinoma. Do u have any references saying that ALK-1 is present on all or nearly all cells of the tumour.

ANSWER:

  

Thank you for contacting us. While I am unaware of any references describingACVRL1 expression in tumors, the human protein atlas (linked below) does show that "distinct cytoplasmic staining with a granular pattern was observed in thyroid cancers, malignant lymphomas and in a few malignant melanomas, colorectal, gastric, pancreatic and renal cancers. Malignant cells in general were negative." http://www.proteinatlas.org/ENSG00000139567/cancer Additionally, because ACVRL1 is88%homologous betweenmouse and human, it will be difficult to find an antibody to that target which will react with mouse and not human epithelial cells. If you are looking to specifically detect mouse endothelial cells, you may be interested in the PLVAP antibody clone MECA-32 (ab27853), which is described in http://www.ncbi.nlm.nih.gov/pubmed/7626790?dopt=AbstractPlus. I hope this helps, please let me know if you need any additional information.

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