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Read our guarantee »Products:Cardiovascular >> Angiogenesis >> Growth Factors >> TGF
Anti-ACVRL1 antibody
See all ACVRL1 products (7) ...
Rabbit polyclonal to ACVRL1
ELISA, WB, IHC-Pmore details
Reacts with
Mouse, Human
A KLH conjugated synthetic peptide selected from the sequence of human ACVRL1 within aa 1-100 (N-terminal).
Mouse heart tissue lysate and hepatocarcinoma tissue
Liquid
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Preservative: 0.09% Sodium Azide
Constituents: PBS
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Protein G purified
This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
Polyclonal
IgG
Cardiovascular >> Vasculature >> Endothelium
Signal Transduction >> Growth Factors/Hormones >> TGF
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Signal Transduction >> Metabolism >> Amino Acids
Cardiovascular >> Angiogenesis >> Growth Factors >> TGF
Our Abpromise guarantee covers the use of ab37807 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: 1/1000
WB: 1/100 - 1/500.Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).
IHC-P: 1/50 - 1/100.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.
Membrane.
Target information above from: UniProt accessionP37023
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Western blot - ACVRL1 antibody (ab37807)

Anti-ACVRL1 antibody (ab37807) at 1/100 dilution + mouse heart tissue lysate
Predicted band size : 56 kDa
Observed band size : 56 kDa
Additional bands at : 25 kDa,45 kDa,70 kDa. We are unsure as to the identity of these extra bands.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ACVRL1 antibody (ab37807)

ab37807 at a 1/50 dilution detecting ACVRL1 expression in human hepatocarcinoma tissue (a peroxidase-conjugated secondary antibody, followed by AEC staining was used).
These data demonstrate the suitability of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
ab37807 has not yet been referenced specifically in any publications.
Publishing research using ab37807? Please let us know so that we can cite the reference in this datasheet
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Anti-ACVRL1 antibody (ab37807) at 1/100 dilution + mouse heart tissue lysate
Predicted band size : 56 kDa
Observed band size : 56 kDa
Additional bands at : 25 kDa,45 kDa,70 kDa. We are unsure as to the identity of these extra bands.

ab37807 at a 1/50 dilution detecting ACVRL1 expression in human hepatocarcinoma tissue (a peroxidase-conjugated secondary antibody, followed by AEC staining was used).
These data demonstrate the suitability of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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