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Overview

  • Product nameACVRL1 peptide (491-503)See all ACVRL1 proteins and peptides ...
  • Protein descriptionSynthetic peptide: C-KISNSPEKPKVIQ, corresponding to amino acids 491-503 of Human ACVRL1.

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Concentration information loading...
  • SequenceC-KISNSPEKPKVIQ
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab10179.

    • Protein info

    • Alternative names
        Activin A receptorActivin A receptor type II like 1Activin A receptor, type II like kinase 1
        Activin receptor like kinase 1Activin receptor-like kinase 1ACVL1_HUMANACVRL1ACVRLK1ALK-1ALK1HHTHHT2ORW2Osler Rendu Weber syndrome 2Serine/threonine protein kinase receptor R3Serine/threonine-protein kinase receptor R3SKR3TGF B superfamily receptor type ITGF-B superfamily receptor type ITSR-ITSR1
      see all
  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
  • Involvement in diseaseDefects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P37023 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for ACVRL1 peptide (491-503) (ab23196)

    ab23196 has not yet been referenced specifically in any publications.

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