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Overview

  • Product nameACVRL1 protein (Active)See all ACVRL1 proteins and peptides ...
  • Protein descriptionRecombinant human ACVRL1 fragment (144-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 64kDa. Swiss ID = P37023.
  • Expression hostBaculovirus infected sf9 cells

    • Properties

  • Purification notesThe purity of ab70317 was determined to be >80% by densitometry,
  • Biological activityThe specific activity of ab70317 was determined to be 22 nmol /min/mg.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab70317 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Functional Studies
  • Application notesKinase Assay: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        Activin A receptorActivin A receptor type II like 1Activin A receptor, type II like kinase 1
        Activin receptor like kinase 1Activin receptor-like kinase 1ACVL1_HUMANACVRL1ACVRLK1ALK-1ALK1HHTHHT2ORW2Osler Rendu Weber syndrome 2Serine/threonine protein kinase receptor R3Serine/threonine-protein kinase receptor R3SKR3TGF B superfamily receptor type ITGF-B superfamily receptor type ITSR-ITSR1
      see all
  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
  • Involvement in diseaseDefects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P37023 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    ACVRL1 protein (Active) images

    • SDS-PAGE - ACVRL1 protein (Active) (ab70317)
      SDS-PAGE - ACVRL1 protein (Active) (ab70317)
      SDS showing ACVRL1 at approximately 64kDa.
    • Functional Studies - ACVRL1 protein (Active) (ab70317)
      Functional Studies - ACVRL1 protein (Active) (ab70317)
      Kinase assay to demonstrate specific activity.

    References for ACVRL1 protein (Active) (ab70317)

    ab70317 has not yet been referenced specifically in any publications.

    Publishing research using ab70317 ? Please let us know so that we can cite the reference in this datasheet

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