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Overview

  • Product nameACVRL1 protein (Active)See all ACVRL1 proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to amino acids 144-503 of Human ACVRL1, expressed by baculovirus in Sf9 insect cells using an N terminal proprietary tag. (NM_000020) This peptide was used as an immunogen for ab37807 - ACVRL1 antibody.
  • Expression hostBaculovirus infected sf9 cells

    • Properties

  • Purification notesPurity of ab84543 was determined to be >80% by densitometry.
  • Biological activityThe specific activity of ab84543 was determined to be 22 nmol/min/mg by activity assay.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
  • Concentration information loading...
  • Additional notesIt is recommended to store ab84543 at -80ºC in glycerol to preserve the activity of the protein.
  • Sequence notesRRRQEKQRGL HSELGESSLI LKASEQGDSM LGDLLDSDCT TGSGSGLPFL VQRTVARQVA LVECVGKGRY GEVWRGLWHG ESVAVKIFSS RDEQSWFRET EIYNTVLLRH DNILGFIASD MTSRNSSTQL WLITHYHEHG SLYDFLQRQT LEPHLALRLA VSAACGLAHL HVEIFGTQGK PAIAHRDFKS RNVLVKSNLQ CCIADLGLAV MHSQGSDYLD IGNNPRVGTK RYMAPEVLDE QIRTDCFESY KWTDIWAFGL VLWEIARRTI VNGIVEDYRP PFYDVVPNDP SFEDMKKVVC VDQQTPTIPN RLAADPVLSG LAQMMRECWY PNPSARLTAL RIKKTLQKIS NSPEKPKVIQ
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab84543 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB
    Functional Studies
    SDS-PAGE
  • Application notesKinase Assay: Use at an assay dependent dilution.
    SDS-PAGE: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 56 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        Activin A receptorActivin A receptor type II like 1Activin A receptor, type II like kinase 1
        Activin receptor like kinase 1Activin receptor-like kinase 1ACVL1_HUMANACVRL1ACVRLK1ALK-1ALK1HHTHHT2ORW2Osler Rendu Weber syndrome 2Serine/threonine protein kinase receptor R3Serine/threonine-protein kinase receptor R3SKR3TGF B superfamily receptor type ITGF-B superfamily receptor type ITSR-ITSR1
      see all
  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
  • Involvement in diseaseDefects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P37023 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    ACVRL1 protein (Active) images

    • Functional Studies - ACVRL1 protein (Active) (ab84543)
      Functional Studies - ACVRL1 protein (Active) (ab84543)
      The specific activity of ab84543 was determined to be 22 nmol/min/mg by activity assay.
    • SDS-PAGE - ACVRL1 protein (Active) (ab84543)
      SDS-PAGE - ACVRL1 protein (Active) (ab84543)
      Purity of ab84543 was determined to be >80% by densitometry. Lane 1 MW marker, lane 2 ACVRL1.

    References for ACVRL1 protein (Active) (ab84543)

    ab84543 has not yet been referenced specifically in any publications.

    Publishing research using ab84543 ? Please let us know so that we can cite the reference in this datasheet

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