Overview
Product nameACVRL1 protein (Tagged)See all ACVRL1 proteins and peptides ...
Protein descriptionRecombinant full length Human Activin Receptor Like Kinase 1 (amino acids 22-503) with N terminal proprietary tag; Predicted MWt 78.76 kDa (inclusive of tag).
Uniprot accessionP37023
Molecular weight78.760kDa inclusive of tags
Protein length482 amino acids
Expression hostWheat germ
Properties
E.C. Number2.7.11.30
FormLiquid
Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Storage bufferpH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
Concentration information loading...
Additional notesProtein concentration is above or equal to 0.05 µg/µl.
Best used within three months from the date of receipt.
Sequence notesDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGR HPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSL VLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLW RVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSD CTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLW HGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALR LAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSN LQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVL DEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDY RPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVL SGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKV IQ
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab132046
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Application
|
Notes |
| WB |
WB: Use at an assay dependent concentration. |
| SDS-PAGE |
SDS-PAGE: Use at an assay dependent concentration. |
| ELISA |
ELISA: Use at an assay dependent concentration. |
Protein info
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Alternative names
Activin A receptorActivin A receptor type II like 1Activin A receptor, type II like kinase 1
Activin receptor like kinase 1Activin receptor-like kinase 1ACVL1_HUMANACVRL1ACVRLK1ALK-1ALK1HHTHHT2ORW2Osler Rendu Weber syndrome 2Serine/threonine protein kinase receptor R3Serine/threonine-protein kinase receptor R3SKR3TGF B superfamily receptor type ITGF-B superfamily receptor type ITSR-ITSR1
see all
FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
Involvement in diseaseDefects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.
Cellular localizationMembrane.
ACVRL1 protein (Tagged) images
References for ACVRL1 protein (Tagged) (ab132046)
ab132046
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
SDS-PAGE - Activin Receptor Like Kinase 1 protein (Tagged) (ab132046)12.5% SDS-PAGE analysis of ab132046 stained with Coomassie Blue.