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ADAM10 peptide (Aminoterminal end) (ab41167)

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Overview

  • Product nameADAM10 peptide (Aminoterminal end)See all ADAM10 proteins and peptides ...
  • Protein descriptionThis peptide was used as an immunogen for ab39153 - ADAM10 antibody - Aminoterminal end.

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab41167 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA
    WB
  • Application notesELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab39153. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        A disintegrin and metalloprotease domain 10A Disintegrin And Metalloproteinase Domain 10AD 10
        AD10ADA10_HUMANADAM 10ADAM metallopeptidase domain 10ADAM10CD 156cCD156cCD156c antigenCDw156disintegrin and metalloproteinase domain containing protein 10Disintegrin and metalloproteinase domain-containing protein 10HsT 18717HsT18717kuzKuzbanianKuzbanian protein homologMADMMammalian disintegrin metalloproteaseMammalian disintegrin-metalloprotease
      see all
  • FunctionCleaves the membrane-bound precursor of TNF-alpha at '76-Ala-
    -Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis.
  • Tissue specificityExpressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
  • Sequence similaritiesContains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationCell membrane. Endomembrane system. Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.

    • Target information above from: UniProt accession O14672 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for ADAM10 peptide (Aminoterminal end) (ab41167)

    ab41167 has not yet been referenced specifically in any publications.

    Publishing research using ab41167 ? Please let us know so that we can cite the reference in this datasheet

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    Is ADAM-10 peptide (ab41167) able to retain enzyme activity and cleave E-cadherin in vitro?

    Thank you for your enquiry. The ab41167 peptide is not enzymatically active. The immunogenic　synthetic peptides can be used as antibody-neutralizing peptides but are not　full-size active enzymes. Therfore, it will not be able to cleave E-cadherin. ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"