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Overview

  • Product nameADAM10 peptideSee all ADAM10 proteins and peptides ...
  • Protein descriptionSynthetic peptide: PQRQRPRESYQMGHMRR, corresponding to amino acids 732-748 of ADAM10

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPBS with 0.1% BSA 0.02% sodium azide pH7.2
  • Concentration information loading...
  • Sequence notesPQRQRPRESYQMGHMRR Amino acids 732 to 748 of human ADAM10 (1)
  • SequencePQRQRPRESYQMGHMRR
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab7868 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Blocking
  • Application notesThe peptide is used for blocking the activity of anti-ADAM10.Incubating the peptide with equal volume of antibody for 30 min at 37°C usually completely blocksthe antibody activity in Western blotting.

    • Protein info

    • Alternative names
        A disintegrin and metalloprotease domain 10A Disintegrin And Metalloproteinase Domain 10AD 10
        AD10ADA10_HUMANADAM 10ADAM metallopeptidase domain 10ADAM10CD 156cCD156cCD156c antigenCDw156disintegrin and metalloproteinase domain containing protein 10Disintegrin and metalloproteinase domain-containing protein 10HsT 18717HsT18717kuzkuzbanianKuzbanian protein homologMADMMammalian disintegrin metalloproteaseMammalian disintegrin-metalloprotease
      see all
  • FunctionCleaves the membrane-bound precursor of TNF-alpha at '76-Ala-
    -Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis.
  • Tissue specificityExpressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
  • Sequence similaritiesContains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationCell membrane. Endomembrane system. Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.

    • Target information above from: UniProt accession O14672 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for ADAM10 peptide (ab7868)

    ab7868 has not yet been referenced specifically in any publications.

    Publishing research using ab7868 ? Please let us know so that we can cite the reference in this datasheet

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    Votes: Highest First

    Would like to know if ADAM10 anti-body reacts with murine tissues-what is the immunogen-goat anti-human or what

    ab7868 is a peptide, sequence PQRQRPRESYQMGHMRR corresponding to amino acids 732 to 748 of human ADAM10. ab1997 is Rabbit polyclonal to ADAM10, the immunogen was the peptide ab7868.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"