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Overview

  • Product nameADAM10 peptideSee all ADAM10 proteins and peptides ...
  • Protein descriptionThis peptide was used as an immunogen for ab84595 - ADAM10 antibody.

    • Properties

  • Purity70 - 90% by HPLC
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab94389 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Blocking BL: Use at an assay dependent concentration. The product can be used in blocking studies with ab84595.
  • Application notesThis peptide can be used with studies using ab84595.

    • Protein info

    • Alternative names
        A disintegrin and metalloprotease domain 10A disintegrin and metalloproteinase domain 10AD 10
        AD10ADA10_HUMANADAM 10ADAM metallopeptidase domain 10ADAM10CD 156cCD156cCD156c antigenCDw156disintegrin and metalloproteinase domain containing protein 10Disintegrin and metalloproteinase domain-containing protein 10HsT 18717HsT18717KuzKuzbanianKuzbanian protein homologMADMMammalian disintegrin metalloproteaseMammalian disintegrin-metalloprotease
      see all
  • FunctionCleaves the membrane-bound precursor of TNF-alpha at '76-Ala-
    -Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis.
  • Tissue specificityExpressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
  • Sequence similaritiesContains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationCell membrane. Endomembrane system. Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.

    • Target information above from: UniProt accession O14672 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for ADAM10 peptide (ab94389)

    ab94389 has not yet been referenced specifically in any publications.

    Publishing research using ab94389 ? Please let us know so that we can cite the reference in this datasheet

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