ADAM10 peptide (ab94389)
Our Abpromise guarantee covers the use of ab94389 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Blocking||BL: Use at an assay dependent concentration. The product can be used in blocking studies with ab84595.|
- A disintegrin and metalloprotease domain 10A disintegrin and metalloproteinase domain 10AD 10
- AD10ADA10_HUMANADAM 10ADAM metallopeptidase domain 10ADAM10CD 156cCD156cCD156c antigenCDw156disintegrin and metalloproteinase domain containing protein 10Disintegrin and metalloproteinase domain-containing protein 10HsT 18717HsT18717KuzKuzbanianKuzbanian protein homologMADMMammalian disintegrin metalloproteaseMammalian disintegrin-metalloprotease
-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis.
Contains 1 peptidase M12B domain.
modificationsThe precursor is cleaved by a furin endopeptidase.
References for ADAM10 peptide (ab94389)
ab94389 has not yet been referenced specifically in any publications.