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Overview

  • Product nameADAM17 peptideSee all ADAM17 proteins and peptides ...

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPBS with 0.1% BSA 0.02% sodium azide pH7.2
  • Concentration information loading...
  • Sequence notesASFKLQRQNRVDSKETE Amino acids 807 to 823 of human TACE (1,2)
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab7881 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Blocking
  • Application notesThe peptide is used for blocking the activity of anti-TACE (ab2051).Incubating the peptide with equal volume of antibody for 30 min at 37°C usually completely blocksthe activity of anti-TACE in Western blotting.

    • Protein info

    • Alternative names
        A disintegrin and metalloproteinase domain 17A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)ADA17_HUMAN
        ADAM 17ADAM metallopeptidase domain 17ADAM17ADAM17 proteinCD 156bCD156bCD156b antigenCSVPDisintegrin and metalloproteinase domain-containing protein 17MGC71942Snake venom like proteaseSnake venom-like proteaseTACETNF alpha convertaseTNF alpha converting enzymeTNF-alpha convertaseTNF-alpha-converting enzymeTumor Necrosis Factor Alpha Converting Enzyme
      see all
  • FunctionCleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.
  • Tissue specificityUbiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
  • Sequence similaritiesContains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
  • DomainMust be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    The precursor is cleaved by a furin endopeptidase.
    Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P78536 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for ADAM17 peptide (ab7881)

    ab7881 has not yet been referenced specifically in any publications.

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