• Product nameAnti-ADAM2 antibodySee all ADAM2 primary antibodies ...
  • Description
    Rabbit polyclonal to ADAM2
  • Specificityab50642 recognizes the 735 and 716 amino acid forms of ADAM-2.
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide based on the amino end of the metalloproteinase domain of human ADAM-2.



Our Abpromise guarantee covers the use of ab50642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
  • Application notesWB: 1/1000 - 1/5000. Predicted molecular weight: 64 kDa. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionSperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
    • Tissue specificityExpressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
    • Sequence similaritiesContains 1 disintegrin domain.
      Contains 1 EGF-like domain.
      Contains 1 peptidase M12B domain.
    • DomainA tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
    • Post-translational
      The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.
    • Cellular localizationMembrane.
    • Target information above from: UniProt accession Q99965 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • A disintegrin and metalloproteinase domain 2 antibody
      • ADAM 2 antibody
      • ADAM metallopeptidase domain 2 antibody
      • Adam2 antibody
      • ADAM2_HUMAN antibody
      • AI323749 antibody
      • Cancer/testis antigen 15 antibody
      • CRYN1 antibody
      • CRYN2 antibody
      • CT15 antibody
      • Disintegrin and metalloproteinase domain-containing protein 2 antibody
      • Fertilin beta antibody
      • Fertilin subunit beta antibody
      • Ftnb antibody
      • PH 30 antibody
      • PH 30b antibody
      • PH-30 antibody
      • PH30 antibody
      • Ph30 beta antibody
      • PH30-beta antibody
      see all

    Anti-ADAM2 antibody images

    • All lanes : Anti-ADAM2 antibody (ab50642) at 1/1000 dilution

      Lane 1 : ST Lysate (treated with IL1-alpha) at 25 µl
      Lane 2 : ST Lysate (treated with IL1-alpha) at 20 µl
      Lane 3 : ST Lysate (treated with IL1-alpha) at 15 µl
      Lane 4 : ST Lysate (treated with IL1-alpha) at 10 µl

      Predicted band size : 64 kDa

    References for Anti-ADAM2 antibody (ab50642)

    ab50642 has not yet been referenced specifically in any publications.

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