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Overview

  • Product nameAnti-ADAM2 antibodySee all ADAM2 primary antibodies ...
  • Description
    Rabbit polyclonal to ADAM2
  • Specificityab50642 recognizes the 735 and 716 amino acid forms of ADAM-2.
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide based on the amino end of the metalloproteinase domain of human ADAM-2.

Properties

Applications

Our Abpromise guarantee covers the use of ab50642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
  • Application notesWB: 1/1000 - 1/5000. Predicted molecular weight: 64 kDa. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionSperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
    • Tissue specificityExpressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
    • Sequence similaritiesContains 1 disintegrin domain.
      Contains 1 EGF-like domain.
      Contains 1 peptidase M12B domain.
    • DomainA tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
    • Post-translational
      modifications      The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.
    • Cellular localizationMembrane.

      • Target information above from: UniProt accession Q99965 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          A disintegrin and metalloproteinase domain 2 antibodyADAM 2 antibodyADAM metallopeptidase domain 2 antibody
          Adam2 antibodyADAM2_HUMAN antibodyAI323749 antibodyCancer/testis antigen 15 antibodyCRYN1 antibodyCRYN2 antibodyCT15 antibodyDisintegrin and metalloproteinase domain-containing protein 2 antibodyFertilin beta antibodyFertilin subunit beta antibodyFtnb antibodyPH 30 antibodyPH 30b antibodyPH-30 antibodyPH30 antibodyPh30 beta antibodyPH30-beta antibody
        see all

      Anti-ADAM2 antibody images

      • Western blot - ADAM2 antibody (ab50642)
        Western blot - ADAM2 antibody (ab50642)
        All lanes : Anti-ADAM2 antibody (ab50642) at 1/1000 dilution

        Lane 1 : ST Lysate (treated with IL1-alpha) at 25 µl
        Lane 2 : ST Lysate (treated with IL1-alpha) at 20 µl
        Lane 3 : ST Lysate (treated with IL1-alpha) at 15 µl
        Lane 4 : ST Lysate (treated with IL1-alpha) at 10 µl


        Predicted band size : 64 kDa

      References for Anti-ADAM2 antibody (ab50642)

      ab50642 has not yet been referenced specifically in any publications.

      Publishing research using ab50642 ? Please let us know so that we can cite the reference in this datasheet

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