ADAM20 peptide (Catalytic domain) (ab41221)
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
Our Abpromise guarantee covers the use of ab41221 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- A disintegrin and metalloproteinase domain 20A disintegrin and metalloproteinase domain 20 preproproteinADA20_HUMAN
- ADAM 20ADAM metallopeptidase domain 20ADAM20Disintegrin and metalloproteinase domain-containing protein 20EC 3.4.24.OTTHUMP00000236151
Contains 1 EGF-like domain.
Contains 1 peptidase M12B domain.
The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
modificationsHas no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated.
References for ADAM20 peptide (Catalytic domain) (ab41221)
ab41221 has not yet been referenced specifically in any publications.